3-[N-(2-Sulfanylpropanoyl)glycyl]-1,3-thiazolidine-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[N-(2-Sulfanylpropanoyl)glycyl]-1,3-thiazolidine-4-carboxylic acid
• 英文别名: 3-[2-(2-sulfanylpropanoylamino)acetyl]-1,3-thiazolidine-4-carboxylic acid
• 化学式: C₉H₁₄N₂O₄S₂
• 分子量: 278.4
• InChiKey: UGHACTSHTBCZGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Thiazolidine-4-carboxylic-acid derivative, process for its preparation and pharmaceutical compositions containing it
  申请人：YASON S.r.l

  公开号：EP0079464A1

  公开（公告）日：1983-05-25

  The present invention relates to the 3-[N-(2-mercaptopropionyl-amino-acetyl)]-tetrahydro-thiazolyl-4-carboxylic acid, a process for its preparation characterized by reacting an activated derivative of benzoylmercapto-propionylglycine with a metal salt of 4-carboxy-thiazolidine and subsequent debenzoylation, and pharmaceutical compositions containing it, endowed with a marked inhibitory activity of the angiotensin converting enzyme (ACE).

  本发明涉及 3-[N-(2-巯基丙酰基-氨基-乙酰基)]-四氢-噻唑-4-羧酸，其制备方法的特点是将苯甲酰巯基丙酰基甘氨酸的活化衍生物与 4-羧基噻唑烷的金属盐反应，然后进行去苯甲酰化，本发明还涉及含有该物质的药物组合物，该药物组合物具有明显的血管紧张素转换酶（ACE）抑制活性。
• [EN] L-THIAZOLIDINE-4-CARBOXYLIC ACID DERIVATIVE, PROCESSES FOR THE PREPARATION THEREOF AND THE USE THEREOF IN THERAPY
  申请人：——

  公开号：WO1993018059A2

  公开（公告）日：1993-09-16

  [EN] L-3-[[N-[2-(2-thenoyl)thiopropionyl]glycyl]]thiazolidine-4-carboxylic acid having interesting antielastase, antiemphysema, mucolytic-expectorant, antioxidant (radical-scavenger), antibronchospastic, antitussive, antiinflammatory, hepatoprotecting activities and a low toxicity; the processes for the preparation thereof and pharmaceutical compositions containing it.
  [FR] L'invention concerne l'acide L-3-[[N-[2-(-thénoyle)thiopropionyle]glycyle]]thiazolidine-4-carboxylique présentant d'intéressantes activités anti-élastase, anti-emphysème, mucolytique-expectorant, anti-oxydantes (piégeur de radicaux), anti-bronchopastiques, anti-tussives, anti-inflammatoires, hématoprotectrices, ainsi qu'une faible toxicité; ses procédés de préparation et des compositions pharmaceutiques le contenant.