arginine octyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: arginine octyl ester
• 英文别名: Octyl 2-amino-5-(diaminomethylideneamino)pentanoate
• 化学式: C₁₄H₃₀N₄O₂
• 分子量: 286.418
• InChiKey: HMDUQDMYHUOZDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Sustainded-release composition including amorphous polymer
  申请人：University Technology Corporation

  公开号：US20020132007A1

  公开（公告）日：2002-09-19

  Provided is a sustained release composition for sustained release of a pharmaceutical substance. The composition includes a biocompatible polymer that is highly amorphous and a pharmaceutical substance in a hydrophobic ion complex with an amphiphilic material. Also provided a compressed antisolvent method for manufacturing the composition, various product forms incorporating the composition and various uses for the composition.

  提供了一种用于缓慢释放药物物质的缓慢释放组合物。该组合物包括一种高度非晶态的生物相容性聚合物和一种与一种两性物质形成疏水离子复合物的药物物质。还提供了一种压缩反溶剂法制造该组合物的方法，包括该组合物的各种产品形式以及该组合物的各种用途。
• Biocompatible cationic detergents and uses therefor
  申请人：University Technology Corporation

  公开号：US20020032166A1

  公开（公告）日：2002-03-14

  Provided is a method for preparing a true, homogeneous solution of a pharmaceutical substance dissolved in an organic solvent in which the pharmaceutical substance is not normally soluble. Solubilization is obtained by forming a hydrophobic ion pair complex involving the pharmaceutical substance and an amphiphilic material. The resulting organic solution may be further processed to prepare pharmaceutical powders. A biodegradable polymer may be co-dissolved with the pharmaceutical substance and the amphiphilic material and may be incorporated into a pharmaceutical powder. A preferred method for preparing pharmaceutical powders is to subject the organic solution to gas antisolvent precipitation using a supercritical gas antisolvent such as carbon dioxide. Also provided is a method for making hollow particles having a fiber-like shape which would provide enhanced retention time in the stomach if ingested by a human or animal host. Further provided are novel biocompatible cationic surfactants and uses therefor, including the delivery, in vitro and in vivo, of nucleic acids into cells to transform the cells.

  提供了一种制备药物物质在有机溶剂中真正均质溶解的方法，其中药物物质通常不溶于有机溶剂。通过形成涉及药物物质和两性分子材料的疏水离子对复合物来获得溶解度。所得到的有机溶液可以进一步处理以制备药物粉末。生物可降解聚合物可以与药物物质和两性分子材料共溶，并可以并入药物粉末中。制备药物粉末的首选方法是将有机溶液经过超临界气体反溶剂沉淀使用超临界气体反溶剂如二氧化碳。此外，提供了一种制备纤维状空心粒子的方法，如果被人类或动物宿主吞咽，将提供增强的胃滞留时间。还提供了新型生物相容阳离子表面活性剂及其用途，包括将核酸在体外和体内传递到细胞中以转化细胞。
• SUSTAINED-RELEASE COMPOSITION INCLUDING AMORPHOUS POLYMER
  申请人：University Technology Corporation

  公开号：EP1073419A2

  公开（公告）日：2001-02-07
• EP1073419A4
  申请人：——

  公开号：EP1073419A4

  公开（公告）日：2009-03-25
• COMPOSITIONS AND METHODS FOR CONTROLLED-RELEASE DELIVERY AND INCREASED POTENCY OF PHARMACEUTICALS VIA HYDROPHOBIC ION-PAIRING
  申请人：University Technology Corporation

  公开号：EP1225916A1

  公开（公告）日：2002-07-31