(5S,6R,7E,9E,11Z,13E)-5,6,15-trihydroxy-15-methylicosa-7,9,11,13-tetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5S,6R,7E,9E,11Z,13E)-5,6,15-trihydroxy-15-methylicosa-7,9,11,13-tetraenoic acid
• 化学式: C₂₁H₃₄O₅
• 分子量: 366.5
• InChiKey: YATRXCCXYFPYPD-NQIXYTNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• LIPOXIN ANALOGS AND METHODS FOR THE TREATMENT OF PERIODONTAL DISEASE
  申请人：Van Dyke Thomas E.

  公开号：US20110064677A1

  公开（公告）日：2011-03-17

  This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond theoral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
• US7700650B2
  申请人：——

  公开号：US7700650B2

  公开（公告）日：2010-04-20
• US8093417B2
  申请人：——

  公开号：US8093417B2

  公开（公告）日：2012-01-10