(5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxy-15-methylicosa-7,9,11,13-tetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxy-15-methylicosa-7,9,11,13-tetraenoic acid
• 化学式: C₂₁H₃₄O₅
• 分子量: 366.5
• InChiKey: YATRXCCXYFPYPD-IFAWBJONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Lipoxin compounds
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：EP2107050A1

  公开（公告）日：2009-10-07

  Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. These small molecules are useful for treating vasoconstrictive, inflammatory, myeloid suppressive, cardiovascular, and gastrointestinal diseases.

  本研究公开了具有天然脂毒素活性位点但组织半衰期更长的化合物。这些小分子化合物可用于治疗血管收缩性疾病、炎症性疾病、骨髓抑制性疾病、心血管疾病和胃肠道疾病。
• Use of lipoxin analogs to promote cell defense against gram-negative infections
  申请人：The Brigham and Women's Hospital

  公开号：EP1941875B1

  公开（公告）日：2012-09-12
• Modulation of Inflammation Related to Columnar Epithelia
  申请人：Madara L. James

  公开号：US20080064660A1

  公开（公告）日：2008-03-13

  This invention provides pharmaceutical compositions containing lipoxin compounds and therapeutic uses for the compounds in treating or preventing a disease or condition associated with columnar epithelial inflammation. The invention also discloses methods for screening for compounds useful in preventing columnar epithelial inflammation.
• Lipoxin Analogs as Novel Inhibitors of Angiogenesis
  申请人：Serhan N. Charles

  公开号：US20080064749A1

  公开（公告）日：2008-03-13

  The present invention is directed to methods for the prevention or inhibition of angiogenesis. The method is accomplished by the administration of an effective amount of 15-epi-16-(para-fluoro)-phenoxy-lipoxin A 4 , LXA 4 , 15-epi-LXA 4 or 15-R/S-methyl, LXA 4 and pharmaceutically acceptable salts, esters, amides, carboxylic acids, or prodrugs thereof, to a subject in need thereof. As a consequence of the action of the therapeutic agent, angiogenesis is prevented or inhibited in the subject.
• Novel Approach to Anti-Microbial Host Defense with Molecular Shields with Lipoxin Compounds
  申请人：Serhan Charles N.

  公开号：US20080214665A1

  公开（公告）日：2008-09-04

  Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. The BPI inducing agents include, for example, lipoxin compounds.