2-[(5Z)-5-[[4-(azepan-1-yl)phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(5Z)-5-[[4-(azepan-1-yl)phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
• 化学式: C₁₈H₂₀N₂O₃S₂
• 分子量: 376.5
• InChiKey: MSUJNKAWICLLCP-PTNGSMBKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1192143A1

  公开（公告）日：2002-04-03
• [EN] RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS<br/>[FR] DERIVES DE RHODANINE UTILISES DANS UN PROCEDE D'INHIBITION DE L'AGREGATION DE PROTEINES AMYLOIDES ET DE FORMATION D'IMAGES DE DEPOTS AMYLOIDES
  申请人：WARNER LAMBERT CO

  公开号：WO2000076987A1

  公开（公告）日：2000-12-21

  The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula (I) and a method of imaging amyloid deposits using compounds of Formula (I).