(E)-3-cyclopentyloxy-4-methoxybenzaldehyde 4-trifluoromethylpyrimidin-2-ylhydrazone | 312268-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-3-cyclopentyloxy-4-methoxybenzaldehyde 4-trifluoromethylpyrimidin-2-ylhydrazone
• 英文别名: N-[(E)-(3-cyclopentyloxy-4-methoxyphenyl)methylideneamino]-4-(trifluoromethyl)pyrimidin-2-amine
• CAS: 312268-85-2
• 化学式: C₁₈H₁₉F₃N₄O₂
• 分子量: 380.37
• InChiKey: WJYNNCTVALIMOG-FOKLQQMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  68.6
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• CATHECOL HYDRAZONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Cheil Jedang Corporation

  公开号：EP1187817A1

  公开（公告）日：2002-03-20
• US6610715B1
  申请人：——

  公开号：US6610715B1

  公开（公告）日：2003-08-26
• [EN] CATHECOL HYDRAZONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME<br/>[FR] DERIVES DE CATHECOL-HYDRAZONE, PROCEDE DE PREPARATION CORRESPONDANT, ET COMPOSITION PHARMACEUTIQUE RENFERMANT LESDITS DERIVES
  申请人：CHEIL JEDANG CORP

  公开号：WO2000073280A1

  公开（公告）日：2000-12-07

  The present invention provides novel cathecol hydrazone derivatives of formula (I) or pharmaceutically acceptable salts thereof, wherein R1 is C¿1-7? alkyl or C3-7 cycloalkyl; R?2¿ is hydrogen, hydroxy, C¿1-5? alkyl or -CH2CH2C(=O)NH2; R?3 and R4¿ are independently hydrogen, C¿1-7? alkyl, -C(=X)-R?5¿, or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one or two selected from a group consisting of halogen, C¿1-6? alkoxy, nitro, trifluoromethyl, C1-6 alkyl and carboxyl, or R?3 and R4¿ are directly bonded by C¿3-4? containing oxygen, sulfur or nitrogen to form a heterocyclic ring, X is oxygen, sulfur or NH and R?5¿ is C¿1-7? alkyl, -NHR?6¿, CONH¿2? or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one selected from a group consisting of halogen, C1-6 alkoxy, nitrile, trifluoromethyl, C1-6 alkyl and carboxyl, and R?6¿ is hydrogen, hydroxy, NH¿2?, C1-5 alkoxy, C1-5 alkyl, pyridyl or phenyl.