(2S)-2-[[(2S)-2-[[(2S)-2-acetamidopropanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[[(2S)-2-[[(2S)-2-acetamidopropanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid
• 化学式: C₂₀H₂₉N₃O₅
• 分子量: 391.5
• InChiKey: NUYDYINAVKNFLR-JQFCIGGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Monoacetic derivatives of the peptides leu-phe-ala and ala-leu-phe and their use in identifying and destroying tumour cells, viruses and virus-carrying cells
  申请人：Grippa, Leonida

  公开号：EP0627444A1

  公开（公告）日：1994-12-07

  The monoacetic derivatives of tripeptides leucine-phenylalanine-alanine and alanine-leucine-phenylalanine are effective in activating NK lymphocytes to identify and destroy directly, that is without any interference by the immune system, aberrant tumour cells, metastatic cells, viruses and virus-carrying cells, so as to result in an "active immunotherapy". The invention also concerns the use of the said monoacetyl-tripeptides in the treatment and prophylaxis of cancer and viral diseases, as well as the pharmaceutical compositions containing one or both of the said compounds, together wit a suitable carrier and, optionally, with other pharmaceutically active substances.

  亮氨酸-苯丙氨酸-丙氨酸和丙氨酸-亮氨酸-苯丙氨酸三肽的单乙酸衍生物可有效激活 NK 淋巴细胞，使其在不受免疫系统干扰的情况下直接识别并消灭异常肿瘤细胞、转移细胞、病毒和病毒携带细胞，从而形成 "主动免疫疗法"。本发明还涉及上述单乙酰三肽在癌症和病毒性疾病的治疗和预防中的应用，以及含有上述一种或两种化合物的药物组合物，连同合适的载体和其他药用活性物质。