(2E,4E)-(1RS,2RS)-5-[2-(3,5-di-tert-butyl-2-butoxy-phenyl)-cyclopropyl]-3-methyl-penta-2,4-dienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2E,4E)-(1RS,2RS)-5-[2-(3,5-di-tert-butyl-2-butoxy-phenyl)-cyclopropyl]-3-methyl-penta-2,4-dienoic acid
• 英文别名: (2E,4E)-5-[2-(2-butoxy-3,5-ditert-butylphenyl)cyclopropyl]-3-methylpenta-2,4-dienoic acid
• 化学式: C₂₇H₄₀O₃
• 分子量: 412.613
• InChiKey: MVEZDCCYKRPTNZ-NBNZOSCDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• EXPANSION OF RENEWABLE STEM CELL POPULATIONS
  申请人：Gamida-Cell Ltd.

  公开号：US20160097037A1

  公开（公告）日：2016-04-07

  Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

  离体和体内扩增可再生干细胞的方法，扩增的可再生干细胞群体及其用途。
• Expansion of renewable stem cell populations
  申请人：Peled Tony

  公开号：US20050008624A1

  公开（公告）日：2005-01-13

  Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

  可再生干细胞的离体和体内扩增方法，扩增的可再生干细胞群体及其用途。
• Expansion Of Renewable Stem Cell Populations
  申请人：Peled Tony

  公开号：US20110033427A1

  公开（公告）日：2011-02-10

  Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

  可再生干细胞的离体和体内扩增方法、可再生干细胞扩增群体及其用途。
• Treatment of inflammatory diseases by RXR Antagonists
  申请人：Bollag, Werner

  公开号：EP1621191A1

  公开（公告）日：2006-02-01

  Retinoids with retinoid antagonistic activities, especially Retinoid X Receptor antagonists called RXR antagonists, pharmaceutically acceptable salts and pharmaceutically acceptable esters and amides thereof, have been found to be efficacious in the treatment of inflamatory diseases of the skin and mucous membranes, and of other tissues and organs especially by topical or oral administration of RXR antagonists.

  研究发现，具有维甲酸拮抗活性的维甲酸类药物，尤其是被称为 RXR 拮抗剂的维甲酸 X 受体拮抗剂、其药学上可接受的盐类和药学上可接受的酯类和酰胺类药物，特别是通过局部或口服 RXR 拮抗剂，可有效治疗皮肤和粘膜以及其他组织和器官的炎症性疾病。
• EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
  申请人：Peled Tony

  公开号：US20050054097A1

  公开（公告）日：2005-03-10

  Ex-vivo methods of expanding hematopoietic stem cells of hematopoietic mononuclear cells that comprise a major fraction of hematopoietic committed cells and a minor fraction of hematopoietic stem and progenitor cells, expanded populations of hematopoietic stem cells obtained thereby and their uses are disclosed.

  本研究公开了由造血干细胞和祖细胞组成的造血单核细胞的体内外造血干细胞扩增方法、由此获得的造血干细胞扩增群及其用途。