(Z)-but-2-enedioic acid;5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (Z)-but-2-enedioic acid;5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• 化学式: C23H24N2O7S
• 分子量: 472.5
• InChiKey: WQPPVXYMJYHKGZ-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.87
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  168
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Stabilized pharmaceutical composition comprising antidiabetic agent
  申请人：Huang Le

  公开号：US20060089387A1

  公开（公告）日：2006-04-27

  This invention discloses a stabilized pharmaceutical composition comprising an antidiabetic agent and a stabilizer. The preferred stabilizers are selected from the group consisting of ascorbic acid, malic acid, maleic acid, tartaric acid, furmaric acid, citric acid, or combinations thereof. The antidiabetic agent is selected from the group consisting of [(±)5-[[2-(5-ethyl-2-pyridinyl)ethoxyl]phenyl]methyl]-thiazolidine-2,4-dione and (±)5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione. This invention also discloses amorphous forms of said antidiabetic agents and a process of preparation thereof, and a method for medical treatment of diabetic mellitus using said pharmaceutical composition.

  这项发明揭示了一种稳定的药物组合物，包括一种抗糖尿病药物和一种稳定剂。优选的稳定剂选自抗坏血酸、苹果酸、马来酸、酒石酸、富马酸、柠檬酸或它们的组合。抗糖尿病药物选自[(±)5-[[2-(5-乙基-2-吡啶基)乙氧基]苯基]甲基]-噻唑烷-2,4-二酮和(±)5-[4-[2-(N-甲基-N-(2-吡啶基)氨基)乙氧基]苯基]噻唑烷-2,4-二酮。该发明还揭示了所述抗糖尿病药物的非晶形式及其制备方法，以及使用该药物组合物进行糖尿病治疗的方法。
• Methods and materials for treating, detecting, and reducing the risk of developing Alzheimer's Disease
  申请人：Pedersen A. Ward

  公开号：US20050004179A1

  公开（公告）日：2005-01-06

  Disclosed are methods for treating Alzheimer's Disease in a subject and for preventing or inhibiting the development of Alzheimer's Disease in a subject. The methods include administering, to the subject, a material which decreases insulin resistance. Also disclosed is a composition which includes a material that decreases insulin resistance and an antidepressant/anti-anxiety drug. Also disclosed are articles of manufacture which include a container; a material that decreases insulin resistance disposed within the container; and a label affixed to the container and/or an insert disposed in the container, where the label and/or insert indicates and/or suggests that the material can be used to treat, decrease the risk for development of, and/or inhibit the development of Alzheimer's Disease and/or one or more clinical features of Alzheimer's Disease.

  本发明公开了治疗受试者阿尔茨海默病和预防或抑制受试者阿尔茨海默病发展的方法。这些方法包括向受试者施用能降低胰岛素抵抗的物质。还公开了一种组合物，其中包括一种降低胰岛素抵抗的材料和一种抗抑郁/抗焦虑药物。还公开了一些制造品，其中包括容器；置于容器内的降低胰岛素抵抗的材料；以及贴在容器上的标签和/或置于容器内的插页，其中标签和/或插页表明和/或暗示该材料可用于治疗、降低阿尔茨海默病的发病风险和/或抑制阿尔茨海默病的发病和/或阿尔茨海默病的一种或多种临床特征。
• A MEDICINAL AEROSOL FORMULATION
  申请人：Aeropharm Technology Incorporated

  公开号：EP1307243A2

  公开（公告）日：2003-05-07
• EP1307243A4
  申请人：——

  公开号：EP1307243A4

  公开（公告）日：2009-04-29
• METHODS AND MATERIALS FOR TREATING, DETECTING, AND REDUCING THE RISK OF DEVELOPING ALZHEIMER'S DISEASE
  申请人：CREIGHTON UNIVERSITY

  公开号：EP1633344A2

  公开（公告）日：2006-03-15