(R)-3-氨基-3-(1-萘基)-丙酸 | 775280-91-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (R)-3-氨基-3-(1-萘基)-丙酸
• 中文别名: R-3-氨基-3-(1-萘基)丙酸；(R)-3-氨基-3-(1-萘)-丙酸
• 英文名称: (R)-3-Amino-3-(naphthalen-1-yl)propanoic acid
• 英文别名: (3R)-3-amino-3-naphthalen-1-ylpropanoic acid
• CAS: 775280-91-6
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.25
• InChiKey: BIOQBKBTOAMMDG-GFCCVEGCSA-N

物化性质

• 沸点：
  412.3±33.0 °C(Predicted)
• 密度：
  1.252±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• 3-Amino-3-arylpropionic acid n-alkyl esters, process for production thereof, and process for production of optically active 3-amino-3-arylpropionic acids and esters of the antipodes thereto
  申请人：Yamamoto Yasuhito

  公开号：US20060178433A1

  公开（公告）日：2006-08-10

  The present invention is to provide an n-alkyl 3-amino-3-arylpropionate represented by the formula (I): wherein Ar 1 represents an aryl group which may have a substituent(s), provided that a phenyl group and 4-methoxyphenyl group are excluded, R 1 represents an n-propyl group or an n-butyl group, and a process for preparing the same, and its optically active compound and an optically active (S or R)-3-amino-3-arylpropionic acid represented by the formula (III-a): wherein Ar represents an aryl group which may have a substituent(s), and * represents an asymmetric carbon, and a process for preparing an optically active n-alkyl (R or S)-3-amino-3-arylpropionate represented by the formula (IV-a): wherein Ar and R 1 have the same meanings as defined above, * represents an asymmetric carbon, provided that it has a reverse absolute configuration to the compound of the formula (III-a).

  本发明提供了一种n-烷基3-氨基-3-芳基丙酸酯，其化学式表示为(I)：其中，Ar1表示一个芳基基团，可以具有一个或多个取代基，但不包括苯基和4-甲氧基苯基；R1表示一个n-丙基基团或n-丁基基团。本发明还提供了制备该化合物的方法，以及其光学活性化合物和光学活性(S或R)-3-氨基-3-芳基丙酸的化学式表示为(III-a)：其中，Ar表示一个芳基基团，可以具有一个或多个取代基，*表示一个不对称碳，以及制备光学活性n-烷基(R或S)-3-氨基-3-芳基丙酸酯的方法，其化学式表示为(IV-a)：其中，Ar和R1的含义与上述定义相同，*表示一个不对称碳，但其绝对构型与化合物的化学式(III-a)相反。
• Racemic Drug Resolution Using Polymer Supported Chiral Selector
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEAECH

  公开号：US20160208088A1

  公开（公告）日：2016-07-21

  The present invention relates to a process for the separation of enantiomers or resolution of racemic mixtures using high surface area core-shell polymer beads. The present invention further relates to a core-shell functionalized polymer comprising a core which comprises copolymer made from monomers selected from non-aromatic acrylate, ethylene dimethacrylate and divinyl-benzene, a shell which comprises monomers selected from glycidyl ethers of methacrylate and a chiral selector selected from tartaric acid derivatives and amino acids.

  本发明涉及使用高表面积核壳聚合物珠子分离对映体或分离混合物的过程。本发明还涉及一种核壳功能化聚合物，包括一个核，该核由从非芳香族丙烯酸酯、乙二醇二甲基丙烯酸酯和二乙烯基苯中选择的单体共聚而成，一个壳，该壳由从甲基丙烯酸醋酸酯的环氧乙醚和酒石酸衍生物和氨基酸中选择的单体组成的手性选择剂。
• 3-AMINO-3-ARYLPROPIONIC ACID n-ALKYL ESTERS, PROCESS FOR PRODUCTION THEREOF, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 3-AMINO-3-ARYLPROPIONIC ACIDS AND ESTERS OF THE ANTIPODES THERETO
  申请人：Ube Industries, Ltd.

  公开号：EP1621529A1

  公开（公告）日：2006-02-01

  The present invention is to provide an n-alkyl 3-amino-3-arylpropionate represented by the formula (I): wherein Ar1 represents an aryl group which may have a substituent(s), provided that a phenyl group and 4-methoxyphenyl group are excluded, R1 represents an n-propyl group or an n-butyl group, and a process for preparing the same, and its optically active compound and an optically active (S or R)-3-amino-3-arylpropionic acid represented by the formula (III-a): wherein Ar represents an aryl group which may have a substituent(s), and * represents an asymmetric carbon, and a process for preparing an optically active n-alkyl (R or S)-3-amino-3-arylpropionate represented by the formula (IV-a): wherein Ar and R1 have the same meanings as defined above, * represents an asymmetric carbon, provided that it has a reverse absolute configuration to the compound of the formula (III-a).

  本发明旨在提供一种由式（I）代表的 3-氨基-3-芳基丙酸正烷基酯： 其中 Ar1 代表芳基，该芳基可以具有取代基，但不包括苯基和 4-甲氧基苯基，R1 代表正丙基或正丁基、 及其光学活性化合物和由式（III-a）表示的光学活性（S 或 R）-3-氨基-3-芳基丙酸的制备方法： 其中 Ar 代表芳基，该芳基可能具有取代基，* 代表不对称碳、 以及一种制备由式（IV-a）代表的光学活性正烷基（R 或 S）-3-氨基-3-芳基丙酸酯的工艺： 其中 Ar 和 R1 的含义与上述定义相同，* 代表不对称碳，条件是其绝对构型与式 (III-a) 化合物相反。
• US7388112B2
  申请人：——

  公开号：US7388112B2

  公开（公告）日：2008-06-17
• US9809706B2
  申请人：——

  公开号：US9809706B2

  公开（公告）日：2017-11-07