(R)-4-N-Boc-氨基-2-羟基丁酸 | 496918-28-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (R)-4-N-Boc-氨基-2-羟基丁酸
• 中文别名: (R)-4-N-BOC-氨基-2-羟基丁酸
• 英文名称: (R)-4-(tert-butoxycarbonylamino)-2-hydroxybutanoic acid
• 英文别名: (R)-4-N-Boc-amino-2-hydroxybutyric acid；(2R)-2-hydroxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
• CAS: 496918-28-6
• 化学式: C₉H₁₇NO₅
• 分子量: 219.238
• InChiKey: POASMXSJVKADPM-ZCFIWIBFSA-N

物化性质

• 沸点：
  422.8±35.0 °C(Predicted)
• 密度：
  1.204±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2924199090

反应信息

• 作为产物：
  描述：

  methyl (R)-4-((tert-butoxycarbonyl)amino)-2-hydroxybutyrate 在 sodium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 反应 0.5h， 以93%的产率得到(R)-4-N-Boc-氨基-2-羟基丁酸
  参考文献：
  名称：

  DNA sequence selectivity of hairpin polyamide turn units

  摘要：

  A class of hairpin polyamides linked by 3,4-diaminobutyric acid, resulting in a beta-amine residue at the turn unit, showed improved binding affinities relative to their alpha-amino-gamma-turn analogs for particular sequences. We incorporated beta-amino-gamma-turns in six-ring polyamides and determined whether there are any sequence preferences under the turn unit by quantitative footprinting titrations. Although there was an energetic penalty for G.C and C.G base pairs, we found little preference for T.A over A.T at the beta-amino- gamma-turn position. Fluorine and hydroxyl substituted alpha-amino-gamma-turns were synthesized for comparison. Their binding affinities and specificities in the context of six-ring polyamides demonstrated overall diminished affinity and no additional specificity at the turn position. We anticipate that this study will be a baseline for further investigation of the turn subunit as a recognition element for the DNA minor groove. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.072

文献信息

• FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF
  申请人：Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

  公开号：EP3498707A1

  公开（公告）日：2019-06-19

  Provided are an FGFR4 inhibitor with the structure of formula (I) and a preparation method and use thereof. The series of compounds of formula (I) have a very strong inhibitory effect on the FGFR4 kinase activity, and have a very high selectivity; and same can be widely used to prepare drugs for treating cancers, in particular, liver cancer, stomach cancer, prostate cancer, skin cancer, ovarian cancer, lung cancer, breast cancer or colon cancer, and it is expected that same can be developed into a new generation of FGFR4 inhibitor drugs.

  本发明提供了一种具有式(I)结构的FGFR4抑制剂及其制备方法和用途。式（I）系列化合物对FGFR4激酶活性有很强的抑制作用，且具有很高的选择性，可广泛用于制备治疗癌症，特别是肝癌、胃癌、前列腺癌、皮肤癌、卵巢癌、肺癌、乳腺癌或结肠癌的药物，有望开发成新一代FGFR4抑制剂药物。