4-hydroxyglutamic acid hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-hydroxyglutamic acid hydrochloride
• 英文别名: (2S,4S)-2-amino-4-hydroxypentanedioic acid;hydrochloride
• 化学式: C₅H₉NO₅*ClH
• 分子量: 199.591
• InChiKey: WQZUFVNMCLKEGU-GVOALSEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.34
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  121
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-(2-hydroxy-4,5-dimethoxyphenyl)-(2S,4S)-γ-hydroxyglutamic acid 在 盐酸 作用下， 反应 12.0h， 以49 mg的产率得到4-hydroxyglutamic acid hydrochloride
  参考文献：
  名称：

  An amide of l-threo-γ-hydroxyglutamic acid from Justicia ghiesbreghtiana

  摘要：

  A new amide of threo-gamma-hydroxyglutamic acid, justiciamide, was isolated from Justicia ghiesbreghtiana and shown to be (-)-N-(2-hydroxy-4,5-dimethoxyphenyl)-(2 S,4 S)-gamma-hydroxyglutamic acid. Justiciamide is the first amide of an uncommon amino acid found in this genus.

  DOI：

  10.1016/s0031-9422(99)00172-7

文献信息

• An amide of l-threo-γ-hydroxyglutamic acid from Justicia ghiesbreghtiana
  作者：Peter Lorenz、Frank R. Stermitz、Lotfy D. Ismail

  DOI：10.1016/s0031-9422(99)00172-7

  日期：1999.9

  A new amide of threo-gamma-hydroxyglutamic acid, justiciamide, was isolated from Justicia ghiesbreghtiana and shown to be (-)-N-(2-hydroxy-4,5-dimethoxyphenyl)-(2 S,4 S)-gamma-hydroxyglutamic acid. Justiciamide is the first amide of an uncommon amino acid found in this genus.