ethyl (3R)-7-azido-3-(methoxymethoxy)-5-oxoheptanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl (3R)-7-azido-3-(methoxymethoxy)-5-oxoheptanoate
• 化学式: C11H19N3O5
• 分子量: 273.29
• InChiKey: WRDRUVSPQXFAAD-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  76.2
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3 5-dihydroxy heptanoic acid derivatives, and intermediates thereof
  申请人：——

  公开号：US20040186313A1

  公开（公告）日：2004-09-23

  The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH 3 )OCH 3 , R a is a hydroxy-protecting group, and R b is a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation. 1

  本发明涉及制备他汀衍生物的合成方法，该方法通过式 I 的关键中间体进行，其中 X 为卤素、酰氧基、活化的烃氧基、活化的烃硫基或 N（CH 3 ) OCH 3 , R a 是羟基保护基团，而 R b 是羧基保护基团，以及式 I 所示化合物的进一步中间体和通过 Friedel-Crafts 酯化反应制备它们的方法。 1
• PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF STATIN DERIVATIVES ESPECIALLY 7-AMINO 3,5-DIHYDROXY HEPTANOIC ACID DERIVATIVES, AND INTERMEDIATES THEREOF
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1404639A1

  公开（公告）日：2004-04-07
• US7420078B2
  申请人：——

  公开号：US7420078B2

  公开（公告）日：2008-09-02
• [EN] PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF STATIN DERIVATIVES ESPECIALLY 7-AMINO 3,5-DIHYDROXY HEPTANOIC ACID DERIVATIVES, AND INTERMEDIATES THEREOF<br/>[FR] PREPARATION D'INTERMEDIAIRES CONVENANT BIEN POUR LA SYNTHESE DE DERIVES DE STATINE, EN PARTICULIER DE DERIVES D'ACIDE 7-AMINO 3,5-DIHYDROXY HEPTANOIQUE ET DE DERIVES DE CET ACIDE
  申请人：CIBA SC HOLDING AG

  公开号：WO2003004450A1

  公开（公告）日：2003-01-16

  The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH3)OCH3, Ra is a hydroxy-protecting group, and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation.