propan-2-yl (2S)-2-hydroxy-3-[4-(2-hydroxyethoxy)phenyl]propanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: propan-2-yl (2S)-2-hydroxy-3-[4-(2-hydroxyethoxy)phenyl]propanoate
• 化学式: C₁₄H₂₀O₅
• 分子量: 268.3
• InChiKey: NXOLMKYMYHOYIH-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] DERIVATIVES OF PARA-ETHOXY-PHENILLACTIC ACID<br/>[FR] DERIVES D'ACIDE PARA-ETHOXY-PHENILLACTIQUE
  申请人：REDDY RESEARCH FOUNDATION

  公开号：WO2003002508A1

  公开（公告）日：2003-01-09

  The present invention relates to novel antidiabetic compounds, their derivatives, their analogs, their polymorphs and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel 3-aryl-α-oxy substituted propanoic acids of the general formula (I), their derivatives, their analogs, their polymorphs and pharmaceutically acceptable compositions containing them where R1 represents hydroxy or a protecting group such as (C¿1?-C8)alkoxy-CH2-O-, mesylate, tosylate, triflate or halogen atom, R?2¿ represents hydrogen or (C¿1?-C6)alkyl group, R?3¿ represents hydrogen, (C¿1?-C6)alkyl, t-butyldimethyl silyl, trimethyl silyl or alkoxymethyl.