3(5)-[2-(thienyl)vinyl]-1-(4-chlorobenzoyl)-1H-pyrazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3(5)-[2-(thienyl)vinyl]-1-(4-chlorobenzoyl)-1H-pyrazole
• 英文别名: (4-chlorophenyl)[3-(2-(2-thienyl)vinyl)-1H-pyrazol-1-yl]methanone；(4-chlorophenyl)[3-(2-(thien-2-yl)vinyl)-1H-pyrazol-1-yl]methanone；(4-chlorophenyl)-[3-[(E)-2-thiophen-2-ylethenyl]pyrazol-1-yl]methanone
• 化学式: C₁₆H₁₁ClN₂OS
• 分子量: 314.795
• InChiKey: OUACWQDYTFTDOF-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (E)-3-[2-(2-thienyl)vinyl]-1H-pyrazole 、 4-氯苯甲酰氯 在 sodium carbonate 作用下， 以 二氯甲烷 为溶剂， 生成 3(5)-[2-(thienyl)vinyl]-1-(4-chlorobenzoyl)-1H-pyrazole
  参考文献：
  名称：

  [EN] PYRAZOLE DERIVATIVES MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  [FR] MODULATEURS A PETITES MOLECULES DE L'ACTIVITE DU FACTEUR DE CROISSANCE D'HEPATOCYTE (FACTEUR DE DISPERSION)

  摘要：

  公开号：

  WO2004058721A3

文献信息

• METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  申请人：Angion Biomedica Corp.

  公开号：US20180009793A1

  公开（公告）日：2018-01-11

  The present invention provides compositions and formulations of compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein p, R 1 , R 2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of injuries, conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role. In addition, methods are provided for treating such diseases or diseases starting at a time after the onset of the injury, condition or disease.

  本发明提供具有公式（I）及其药学上可接受的衍生物的组合物和配方，其中p，R1，R2和B如本文中一般和在类和子类中所述，并提供其制药组合物以及使用它们治疗HGF/SF或其活性或其激动剂或拮抗剂在治疗中有治疗用途的任何损伤，疾病或疾病的方法。此外，还提供了治疗这些疾病或在损伤，疾病或疾病发病后的时间开始治疗的方法。
• Small molecule modulators of hepatocyte growth factor (scatter factor) activity
  申请人：Zembower E. David

  公开号：US20050113369A1

  公开（公告）日：2005-05-26

  The present invention provides compounds having formula (1): and pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.

  本发明提供具有公式（1）的化合物及其药学上可接受的衍生物，其中R1、R2和B如本文中一般和在各类和亚类中所述，并且还提供了它们的药物组合物，以及使用它们治疗HGF/SF或其活性或其激动剂或拮抗剂在治疗上有治疗作用的任何一种疾病或病症的方法。
• Small-molecule modulators of hepatocyte growth factor / scatter factor activities
  申请人：——

  公开号：US20030045559A1

  公开（公告）日：2003-03-06

  The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

  该发明涉及具有模拟或激活肝细胞生长因子/散发因子（HGF/SF）活性的小有机分子，或抑制或拮抗HGF/SF活性的能力，前者可用于促进组织或器官的血管化，促进伤口或组织愈合，或增强或恢复缺血组织（例如心肌梗死后的心脏）的血流。细胞生长或增殖的抑制对于治疗炎症性疾病（如炎性关节和皮肤疾病）和增殖异常性疾病（如癌症）是有益的。
• Compositions and agents for modulating cellular proliferation and angiogenesis
  申请人：——

  公开号：US20030022924A1

  公开（公告）日：2003-01-30

  The invention is directed to pharmaceutical compositions containing small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction.

  本发明涉及制备含有小有机分子的药物组合物，其具有模拟或激活肝细胞生长因子/散布因子（HGF/SF）活性的能力，可用于促进组织或器官的血管化，促进伤口或组织愈合，或增强或恢复缺血组织（如心肌梗塞后的心脏）的血流。
• Pyrazole derivatives modulators of hepatocyte growth factor (scatter factor) activity
  申请人：Angion Biomedica Corp.

  公开号：EP2292227A2

  公开（公告）日：2011-03-09

  The present invention provides compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and n classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.

  本发明提供了具有式（I）的化合物及其药学上可接受的衍生物，其中 R1、R2 和 B 如本文中一般和 n 类及亚类所述，此外，本发明还提供了其药物组合物及其使用方法，用于治疗 HGF/SF 或其活性或其激动剂或拮抗剂具有治疗作用的多种病症或疾病中的任何一种。