(R)-苯丙香豆素 | 5999-27-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: (R)-苯丙香豆素
• 英文名称: (R)-Phenprocoumon
• 英文别名: 4-hydroxy-3-[(1R)-1-phenylpropyl]chromen-2-one
• CAS: 5999-27-9
• 化学式: C₁₈H₁₆O₃
• 分子量: 280.3
• InChiKey: DQDAYGNAKTZFIW-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

ADMET

代谢

( R )-苯丙香豆素已知的人体代谢物包括4'-羟基苯丙香豆素、6-羟基苯丙香豆素和7-羟基苯丙香豆素。

(R)-phenprocoumon has known human metabolites that include 4'-Hydroxyphenprocoumon, 6-Hydroxyphenprocoumon, and 7-Hydroxyphenprocoumon.

来源:NORMAN Suspect List Exchange

文献信息

• PHENPROCOUMON TTS
  申请人：LTS LOHMANN THERAPIE-SYSTEME AG

  公开号：US20220175717A1

  公开（公告）日：2022-06-09

  The present invention relates to a transdermal therapeutic system for the cutaneous administration of phenprocoumon, comprising an active-substance-impermeable backing layer, an adhesive matrix layer and optionally a removable protective layer, the adhesive matrix layer containing phenprocoumon and at least one matrix polymer, and the content of phenprocoumon in the matrix polymer being ≤7.5 wt. %. By virtue of the low load, it is ensured that the system releases the active ingredient substantially in high release rates, because high thermodynamic activity of the active ingredient is achieved. The present invention also relates to a method for producing a corresponding transdermal therapeutic system.