methyl 2-fluoro-6-[4-[(1R)-1-[[1-(3,3,3-trifluoropropanoylamino)cyclopropanecarbonyl]amino]ethyl]phenyl]benzoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-fluoro-6-[4-[(1R)-1-[[1-(3,3,3-trifluoropropanoylamino)cyclopropanecarbonyl]amino]ethyl]phenyl]benzoate
• 化学式: C₂₃H₂₂F₄N₂O₄
• 分子量: 466.4
• InChiKey: ZGJWENONKIEUCL-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  84.5
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives
  申请人：——

  公开号：US20030220375A1

  公开（公告）日：2003-11-27

  N-Biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

  N-联苯基（取代甲基）氨基环烷甲酰胺衍生物是缓激肽B1受体的拮抗剂或反向激动剂，在治疗或预防与缓激肽B1通路相关的症状，如疼痛和炎症方面是有用的。
• N-biphenylmethyl aminocycloalkanecarboxamide derivatives with a substiituent on the methyl useful as bradykinin antagonists
  申请人：Wood R. Michael

  公开号：US20050084463A1

  公开（公告）日：2005-04-21

  N-Biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

  N-苯基(取代甲基)氨基环烷羧酰胺衍生物是bradykinin B1拮抗剂或反向激动剂，可用于治疗或预防与bradykinin B1通路相关的疼痛和炎症等症状。
• N-biphenylmethyl aminocycloalkanecarboxamide derivatives
  申请人：Wood R Michael

  公开号：US20050085667A1

  公开（公告）日：2005-04-21

  N-Biphenyl(substituted methyl) aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

  N-双苯基（取代甲基）氨基环烷羧酰胺衍生物是Bradykinin B1受体拮抗剂或反向激动剂，可用于治疗或预防与Bradykinin B1通路相关的疼痛和炎症等症状。
• N-BIPHENYLMETHYL AMINOCYCLOALKANECARBOXAMIDE DERIVATIVES
  申请人：Merck & Co., Inc.

  公开号：EP1476419B1

  公开（公告）日：2006-02-01
• N-BIPHENYLMETHYL AMINOCYCLOALKANECARBOXAMIDE DERIVATIVES WITH A SUBSTIITUENT ON THE METHYL USEFUL AS BRADYKININ ANTAGONISTS
  申请人：Merck & Co., Inc.

  公开号：EP1501787B1

  公开（公告）日：2005-11-09