(2S)-2-(2,2-dimethylpropanoylamino)pentanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-(2,2-dimethylpropanoylamino)pentanedioic acid
• 化学式: C₁₀H₁₇NO₅
• 分子量: 231.25
• InChiKey: ONWWGEWHCSHTGO-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Platinum(II) complexes of N-substituted amino dicarboxylates and the preparation method thereof
  申请人：Board of Trustees, EWHA Womans University

  公开号：US20040162342A1

  公开（公告）日：2004-08-19

  Disclosed are a platinum (II) complex of N-substituted amino dicarboxylate showing antitumor activity represented by the following formula (1) and a preparation method thereof: 1 wherein n is 1 or 2; A-A is a diamine selected from the group consisting of trans-(±)-1,2-diaminocyclohexane, ethylenediamine and 2,2-dimethyl-1,3-propanediamine; and R 1 is hydrogen and R 2 is RCO or RSO 2 , wherein R is an alkyl selected from the group consisting of methyl, ethyl, n-propyl, n-butyl and t-butyl or an aryl selected from the group consisting of phenyl and substituted phenyl group, or R 1 R 2 is phthaloyl.

  揭示了一种具有抗肿瘤活性的N-取代氨基二羧酸盐的铂（II）配合物，其化学式如下（1），以及其制备方法：其中n为1或2；A-A是从反式（±）-1,2-二氨基环己烷，乙二胺和2,2-二甲基-1,3-丙二胺组成的二胺；R1为氢，R2为RCO或RSO2，其中R为从甲基、乙基、正丙基、正丁基和叔丁基中选择的烷基，或从苯基和取代苯基组成的芳基，或R1R2为邻苯二甲酰。
• Nitrosated glutamic acid compounds, compositions and methods of use
  申请人：Garvey S. David

  公开号：US20070037821A1

  公开（公告）日：2007-02-15

  The invention describes novel nitrosated glutamic acid compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated glutamic acid compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated glutamic acid compound, and, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (l) treating diseases resulting from elevated levels of gamma-glutamyl transpeptidase and (m) the targeted delivery of compounds and nitric oxide to organs, cells or tissues containing the enzyme gamma-glutamyl transpeptidase.

  该发明描述了新型的硝化谷氨酸化合物及其药学上可接受的盐，以及包含至少一种硝化谷氨酸化合物，和/或至少一种一氧化氮供体和/或至少一种治疗剂的新型组合物。该发明还提供了包含至少一种硝化谷氨酸化合物，和/或至少一种一氧化氮供体化合物和/或至少一种治疗剂的新型试剂盒。该发明还提供了治疗心血管疾病、肾血管疾病、糖尿病、氧化应激引起的疾病、内皮功能障碍、内皮功能障碍引起的疾病、肝硬化、先兆子痫、骨质疏松症、肾病、γ-谷氨酰转移酶水平升高引起的疾病以及将化合物和一氧化氮有针对性地输送到含有γ-谷氨酰转移酶的器官、细胞或组织的方法。
• CROSSLINKABLE DENDRIMERS
  申请人：Wayne State University

  公开号：EP3473249A1

  公开（公告）日：2019-04-24

  The present invention relates to a crosslinkable generation 2 or above poly(amidoamine) (PAMAM) dendrimer having a peripheral group which has been reacted with an amino acid to provide two distinct, orthogonal, chemoselective asymmetrical end groups.

  本发明涉及一种可交联的 2 代或 2 代以上聚（氨基胺）（PAMAM）树枝状聚合物，其外围基团与氨基酸反应生成两个不同的、正交的、具有化学选择性的不对称端基。
• EP1673384A4
  申请人：——

  公开号：EP1673384A4

  公开（公告）日：2007-02-07
• NITROSATED GLUTAMIC ACID COMPOUNDS, COMPOSITIONS AND METHODS OF USE
  申请人：Nitromed, Inc.

  公开号：EP1673384A2

  公开（公告）日：2006-06-28