2,5-bis(3-aminopropylamino)-N-[2-(dioctadecylamino)-2-oxoethyl]pentanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,5-bis(3-aminopropylamino)-N-[2-(dioctadecylamino)-2-oxoethyl]pentanamide
• 化学式: C₄₉H₁₀₂N₆O₂
• 分子量: 807.4
• InChiKey: LAGUSEHJTGJJRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.5
• 重原子数：
  57
• 可旋转键数：
  48
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  126
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• BRANCHED CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM
  申请人：Zhao Hong

  公开号：US20110305769A1

  公开（公告）日：2011-12-15

  The present invention is directed to cationic lipid for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to cholesterol and its derivatives having multiple positively charged moieties via branching spacers, and nanoparticle compositions of oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.

  本发明涉及用于递送寡核苷酸的阳离子脂质以及利用纳米粒子组合物调节靶向基因表达的方法。具体而言，本发明涉及通过分支间隔物具有多个带正电性的衍生物的胆固醇及其衍生物，以及封装在阳离子脂质、融合脂质和PEG脂质混合物中的寡核苷酸纳米粒子组合物。
• MAMMALIAN RNA DEPENDENT RNA POLYMERASE
  申请人：Hahn William

  公开号：US20110243910A1

  公开（公告）日：2011-10-06

  The invention provides compositions comprising a TERT-RMRP or TERT-RNA complex and methods of treating subjects with genetic diseases in which gene silencing is either increased by administering the compositions of the invention or decreased by administering an inhibitor of the RNA-dependent RNA polymerase (RdRP) activity of these compositions. Moreover, the invention provides methods of screening for agonists and antagonists of RdRP activity and TERT-RMRP complex formation. Finally, the invention provides a method of identifying a RNA molecule that forms a complex with a TERT polypeptide and has RdRP activity.

  本发明提供了包括TERT-RMRP或TERT-RNA复合物的组合物，并提供了使用该发明的组合物增加基因沉默或通过给予RNA依赖性RNA聚合酶（RdRP）活性抑制剂来减少基因沉默的治疗遗传疾病的方法。此外，本发明还提供了筛选RdRP活性和TERT-RMRP复合物形成的激动剂和拮抗剂的方法。最后，本发明提供了一种识别形成与TERT多肽复合物并具有RdRP活性的RNA分子的方法。
• NANOPARTICLE COMPOSITIONS FOR NUCLEIC ACIDS DELIVERY SYSTEM
  申请人：Zhao Hong

  公开号：US20110111044A1

  公开（公告）日：2011-05-12

  The present invention is directed to nanoparticle compositions for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.

  本发明涉及纳米颗粒组合物，用于输送寡核苷酸并使用该纳米颗粒组合物调节靶向基因的表达的方法。特别地，该发明涉及封装在阳离子脂质、融合脂质和PEG脂质混合物中的寡核苷酸。
• AMINO ACID LIPIDS AND USES THEREOF
  申请人：Marina Biotech, Inc.

  公开号：US20140037714A1

  公开（公告）日：2014-02-06

  This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  本公开提供了一系列氨基酸脂质化合物和组合物，可用于药物传递、治疗以及疾病和病症的诊断和治疗。氨基酸脂质化合物和组合物可用于向细胞、组织、器官和受试者传递各种药物，例如核酸治疗药物。
• TARGETED OLIGONUCLEOTIDE COMPOSITIONS FOR MODIFYING GENE EXPRESSION
  申请人：Yale University

  公开号：EP2296669A1

  公开（公告）日：2011-03-23