(2S,4S)-1-[(2S)-2-amino-2-(1-ethenylcyclopentyl)acetyl]-4-fluoropyrrolidine-2-carbonitrile

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4S)-1-[(2S)-2-amino-2-(1-ethenylcyclopentyl)acetyl]-4-fluoropyrrolidine-2-carbonitrile
• 化学式: C₁₄H₂₀FN₃O
• 分子量: 265.33
• InChiKey: JEDSJPTWRPSMLF-SDDRHHMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Fluoropyrrolidines as dipeptidyl peptidase inhibitors
  申请人：SmithKline Beecham Corporation

  公开号：EP1862457A2

  公开（公告）日：2007-12-05

  The present invention relates to novel compounds, their use for inhibiting serine proteases, such as dipeptidyl peptidases, such as dipeptidyl peptidase IV (DPP-IV) and to methods for their production and their therapeutic utility.

  本发明涉及新型化合物、它们在抑制丝氨酸蛋白酶（如二肽基肽酶，如二肽基肽酶 IV (DPP-IV)）方面的用途，以及它们的生产方法和治疗用途。
• [EN] FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS<br/>[FR] FLUOROPYRROLIDINES INHIBITRICES DE LA DIPEPTIDYL PEPTIDASE
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2003002531A2

  公开（公告）日：2003-01-09

  The present invention relates to novel compounds of formula (I): , their use for inhibiting serine proteases, such as dipeptidyl peptidases, such as dipeptidyl peptidase IV (DPP-IV) and to methods for their production and their therapeutic utility.