1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(2,6-dichloro-pyridin-4-yl)ethanone oxime | 1026957-08-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(2,6-dichloro-pyridin-4-yl)ethanone oxime
• 英文别名: 1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(2,6-dichloro-4-pyridyl)ethanone oxime；(NE)-N-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(2,6-dichloropyridin-4-yl)ethylidene]hydroxylamine
• CAS: 1026957-08-3
• 化学式: C₁₉H₂₀Cl₂N₂O₃
• 分子量: 395.285
• InChiKey: QLEIMXRDEGHARS-HZHRSRAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  63.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Soft tissue implants and anti-scarring agents
  申请人：Hunter L. William

  公开号：US20050142162A1

  公开（公告）日：2005-06-30

  Soft tissue implants (e.g., breast, pectoral, chin, facial, lip, and nasal implants) are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the implant is placed within an animal.

  软组织植入物（例如乳房、胸肌、下巴、面部、唇部和鼻部植入物）与抗瘢痕剂结合使用，以抑制动物体内植入物放置时可能发生的瘢痕形成。
• Medical implants and anti-scarring agents
  申请人：Hunter L. William

  公开号：US20050177225A1

  公开（公告）日：2005-08-11

  Implants are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the implant is placed within an animal. The agent may be any suitable anti-scarring agent, e.g., a cell cycle inhibitor, and may be used in conjunction with a second pharmaceutical agent, e.g., an antibiotic. Suitable implants include intravascular implants, a vascular graft or wrap implant, an implant for hemodialysis access, an implant that provides an anastomotic connection, ventricular assist implant, a prosthetic heart valve implant, an inferior vena cava filter implant, a peritoneal dialysis catheter implant, a central nervous system shunt, an intraocular lens, an implant for glaucoma drainage, a penile implant, an endotracheal tube, a tracheostomy tube, a gastrointestinal device, and a spinal implant.

  植入物可与抗疤痕剂结合使用，以抑制动物体内植入物时可能产生的疤痕。抗疤痕剂可以是任何合适的抗疤痕剂，如细胞周期抑制剂，也可以与第二种药剂（如抗生素）结合使用。合适的植入物包括血管内植入物、血管移植或包裹植入物、血液透析通路植入物、提供吻合连接的植入物、心室辅助植入物、人工心脏瓣膜植入物、下腔静脉过滤器植入物、腹膜透析导管植入物、中枢神经系统分流器、眼内晶状体、青光眼引流植入物、阴茎植入物、气管插管、气管造口管、胃肠道装置和脊柱植入物。
• Implantable sensors and implantable pumps and anti-scarring agents
  申请人：Hunter L. William

  公开号：US20050186239A1

  公开（公告）日：2005-08-25

  Pumps and sensors for contact with tissue are used in combination with an anti-scarring agent (e.g., a cell cycle inhibitor) in order to inhibit scarring that may otherwise occur when the pumps and sensors are implanted within an animal.

  用于与组织接触的泵和传感器与抗疤痕剂（如细胞周期抑制剂）结合使用，以抑制在动物体内植入泵和传感器时可能出现的疤痕。
• SUBSTITUTED OXIME DERIVATIVES USEFUL AS PDE IV INHIBITORS
  申请人：Celltech Chiroscience Limited

  公开号：EP0766673B1

  公开（公告）日：2002-01-30
• Drug delivery from rapid gelling polymer composition
  申请人：Angiotech International AG

  公开号：US20040225077A1

  公开（公告）日：2004-11-11

  Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.