N-[(1R,4R,9aS)-4-phenyl-1,3,4,6,7,8,9,9a-octahydropyrido[2,1-c][1,4]oxazin-1-yl]-3,4,5-trimethoxybenzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-[(1R,4R,9aS)-4-phenyl-1,3,4,6,7,8,9,9a-octahydropyrido[2,1-c][1,4]oxazin-1-yl]-3,4,5-trimethoxybenzamide
• 化学式: C₂₄H₃₀N₂O₅
• 分子量: 426.5
• InChiKey: RQPNNIOMMKUERI-AXHZCLLHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHODS OF DIAGNOSING, PREVENTING AND TREATING BONE MASS DISEASES
  申请人：Karsenty Gerard

  公开号：US20110152220A1

  公开（公告）日：2011-06-23

  The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1 inhibitors or serotonin receptor antagonists.

  本发明提供了降低或增加患者血清5-羟色胺水平的方法和治疗剂，以分别增加或减少骨量。在优选实施方式中，患者已知患有或有患低骨量疾病（如骨质疏松症）的风险，药剂为TPH1抑制剂或5-羟色胺受体拮抗剂。
• METHODS OF PREVENTING AND TREATING LOW BONE MASS DISEASES
  申请人：Karsenty Gerard

  公开号：US20110281899A1

  公开（公告）日：2011-11-17

  The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1 inhibitors or serotonin receptor antagonists.

  本发明提供了降低或增加患者血清5-羟色胺水平以增加或减少骨量的方法和治疗剂。在优选实施例中，患者已知患有或有患低骨量疾病（如骨质疏松症）的风险，治疗剂为TPH1抑制剂或5-羟色胺受体拮抗剂。
• METHODS OF DIAGNOSING, PREVENTING, AND TREATING BONE MASS DISEASES
  申请人：Karsenty Gerard

  公开号：US20150111908A1

  公开（公告）日：2015-04-23

  The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1 inhibitors or serotonin receptor antagonists.

  本发明提供了降低或增加患者血清5-羟色胺水平以增加或减少骨量的方法和治疗剂。在优选实施例中，患者已知患有或有患低骨量疾病（如骨质疏松症）的风险，所使用的治疗剂为TPH1抑制剂或5-羟色胺受体拮抗剂。
• Nouveaux dérivés amidiques de 1-amino octahydropyrido (2,1-c) (1,4) oxazine, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
  申请人：ADIR ET COMPAGNIE

  公开号：EP0514267B1

  公开（公告）日：1996-06-26
• METHODS OF PREVENTING AND TREATING HYPERLIPIDEMIA OR ATHEROSCLEROSIS
  申请人：Karsenty Gerard

  公开号：US20130338176A1

  公开（公告）日：2013-12-19

  The present invention provides methods and therapeutic agents for lowering serum or plasma serotonin levels in a patient in order to prevent or treat hyperlipidemia or atherosclerosis. In preferred embodiments, the patient is known to have, or to be at risk for, hyperlipidemia or atherosclerosis and the agents are TPH1 inhibitors.