异噻唑并[5,4-b]吡啶-3,4-二胺,N4,7-二乙基-6,7-二氢-6-亚氨基- | 24306-54-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 异噻唑并[5,4-b]吡啶-3,4-二胺,N4,7-二乙基-6,7-二氢-6-亚氨基-
• 中文别名: 4-(氨基甲基)-双环(2.2.2)辛烷-1-羧酸
• 英文名称: 4-Aminomethyl-bicyclo<2.2.2>octan-1-carbonsaeure
• 英文别名: 4-(Aminomethyl)bicyclo[2.2.2]octane-1-carboxylic acid
• CAS: 24306-54-5
• 化学式: C₁₀H₁₇NO₂
• 分子量: 183.25
• InChiKey: PKWPJBDFDHJNER-UHFFFAOYSA-N

物化性质

• 沸点：
  318.5±15.0 °C(Predicted)
• 密度：
  1.226±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2020252396A1

  公开（公告）日：2020-12-17

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral RSV F protein (e.g., Presatovir, MDT 637, JNJ 179, or an analog thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., RSV infections).

  用于治疗病毒感染的组合物和方法包括含有病毒RSV F蛋白抑制剂（例如Presatovir、MDT 637、JNJ 179或其类似物）的共轭物，连接到一个Fc单体、一个Fc结构域和Fc结合肽、一种白蛋白蛋白质或白蛋白结合肽。特别是，这些共轭物可以用于治疗病毒感染（例如RSV感染）。
• Washing composition capable of preventing and ameliorating skin irritation
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0473502A1

  公开（公告）日：1992-03-04

  A washing composition containing one or more compounds having a protease inhibitory activity and dermatologically acceptable components.

  一种洗涤组合物，含有一种或多种具有蛋白酶抑制活性的化合物和皮肤学上可接受的成分。
• Synergistic compositions comprising ascorbate and lysine for states related to extracellular matrix degeneration
  申请人：Rath, Matthias, Dr. med.

  公开号：EP1068868A2

  公开（公告）日：2001-01-17

  A composition for the prevention and treatment of diseases or pathological states related to the degradation of the exctracellular matrix, such as including but not limited to, degenrative diseases, particularly atheriosclerosis, cancer, infection or other inflammatory diseases is disclosed, comprising preparentially compounds of lysine, proline, ascorabte, and their derivates and synthetic analogues and vitamins, pro-vitamins and traceelements.

  本发明公开了一种用于预防和治疗与细胞外基质降解有关的疾病或病理状态（如包括但不限于退化性疾病，特别是动脉粥样硬化、癌症、感染或其他炎症性疾病）的组合物，其中包含赖氨酸、脯氨酸、升麻素及其衍生物和合成类似物以及维生素、维生素原和微量元素的前体化合物。
• Drug delivery system for use in the treatment of vascular and vessel-related pathologies
  申请人：Academisch Medisch Centrum

  公开号：EP2210590A1

  公开（公告）日：2010-07-28

  The present invention relates to a drug delivery system for use in the treatment of vascular and vessel-related pathologies, comprising a drug delivery platform that comprises at least one compound capable of exerting an effect on the formation and/or maintenance of a thrombus in the vessel to be treated. The platform is preferably formed by liposomes that are sterically stabilized by grafting of poly(ethylene glycol) onto the liposome surface. The liposomes may further comprise photosensitizers and targeting molecules. The liposomes may be thermosensitive. The compound is suitably tranexamic acid. The drug delivery system is preferably used for the treatment of port wine stains.

  本发明涉及一种用于治疗血管和血管相关病症的给药系统，该系统包括一个给药平台，该平台包含至少一种能够对待治疗血管中血栓的形成和/或维持产生影响的化合物。该平台最好由脂质体形成，脂质体表面接枝聚乙二醇使其立体稳定。脂质体可进一步包含光敏剂和靶向分子。脂质体可具有热敏性。化合物宜为氨甲环酸。该给药系统最好用于治疗波特酒渍。
• Antifibrinolytic compounds
  申请人：THROMBOLYTICS, LLC

  公开号：US10202331B2

  公开（公告）日：2019-02-12

  The present invention provides novel and antifibrinolytic compounds, processes for their preparation, pharmaceutical and veterinary compositions thereof, and their use in medicine, in particular for the treatment of bleeding. The present application relates to numerous embodiments of chemical structures which in whole or in part mimic or are analogs of the amino acid Lysine such that they bind to specific binding site(s) within specific protein sub structures in the structures of Plasminogen, and/or Plasmin, and/or Plasminogen Activators, and/or Thrombin.

  本发明提供了新型抗纤维蛋白溶解化合物、其制备工艺、药物和兽药组合物及其在医学中的用途，特别是用于治疗出血。本申请涉及许多化学结构的实施方案，这些化学结构全部或部分模仿氨基酸赖氨酸或其类似物，从而使它们与特定蛋白质子结构中的特定结合位点结合，这些蛋白质子结构包括血浆蛋白酶原、和/或血浆蛋白、和/或血浆蛋白酶原激活剂、和/或凝血酶。