(S)-3,4-二氨基丁酸二盐酸盐 | 141318-80-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (S)-3,4-二氨基丁酸二盐酸盐
• 英文名称: (S)-3,4-Diaminobutyric acid dihydrochloride
• 英文别名: (3S)-3,4-diaminobutanoic acid;dihydrochloride
• CAS: 141318-80-1
• 化学式: C4H12Cl2N2O2
• 分子量: 191.05
• InChiKey: CYSOFTBXTQXELE-QTNFYWBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.41
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  89.3
• 氢给体数：
  5
• 氢受体数：
  4

文献信息

• Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：US20030153783A1

  公开（公告）日：2003-08-14

  A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1 where Y is as described in the attached description, starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

  本文描述了一种制备R或S氨基肉碱，R或S磷酸氨基肉碱和R和S 3,4-二氨基丁酸及其衍生物的过程，其化学式如下：1其中Y如附加说明所述，从具有所需化合物相同构型的天冬氨酸出发。该过程在工业上具有优势，因为使用的反应物类型、溶剂体积的减少以及避免中间产物的纯化。
• SYNTHESIS OF (R) AND (S)-AMINOCARNITINE AND DERIVATIVES THEREOF FROM D-AND L-ASPARTIC ACID
  申请人：SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP1581475A1

  公开（公告）日：2005-10-05
• US6822115B2
  申请人：——

  公开号：US6822115B2

  公开（公告）日：2004-11-23
• [EN] SYNTHESIS FO (R) AND (S)-AMINOCARNITINE AND DERIVATIVES THEREOF FROM D-AND L-ASPARTIC ACID<br/>[FR] SYNTHESE DE L'AMINOCARNITINE R ET S ET DERIVES DE CELLE-CI A PARTIR DE L'ACIDE ASPARTIQUE D ET L
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2004063143A1

  公开（公告）日：2004-07-29

  A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the above formula (I), where Y is as described in the attached description, starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.