N-[(2R)-1-[(3-amino-2-hydroxypropyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1-(2-cyclohexylacetyl)pyrrolidine-2-carboxamide;hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(2R)-1-[(3-amino-2-hydroxypropyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1-(2-cyclohexylacetyl)pyrrolidine-2-carboxamide;hydrochloride
• 化学式: C29H41ClN4O4
• 分子量: 545.1
• InChiKey: OUCBLQBWMSIIAH-GVTBEHSKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.69
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  125
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• NOVEL AMIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES
  申请人：Kaken Pharmaceutical Co., Ltd.

  公开号：EP1158996A1

  公开（公告）日：2001-12-05
• EP1158996A4
  申请人：——

  公开号：EP1158996A4

  公开（公告）日：2005-01-12
• [EN] NOVEL AMIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES<br/>[FR] NOUVEAUX DERIVES AMIDE SECRETAGOGUES DE L'HORMONE DE CROISSANCE
  申请人：KAKEN PHARMA CO LTD

  公开号：WO2000048623A1

  公开（公告）日：2000-08-24

  Disclosed are the novel compounds as growth hormone secretagogues represented by structural Formula (I), wherein R1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, or substituted or unsubstituted amino, X is -CO- or -SO¿2?-, Y is Formula (II), wherein n is an integer from 0-4, R?4¿ is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, R?5 and R6¿ are independently selected from hydrogen, substituted or unsubstituted alkyl, or R?5 and R6 or R4 and R5¿ are taken together to form substituted or unsubstituted alkylene, R2 is hydrogen, or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, D is substitued or unsubstituted amino, substituted or unsubstituted alkoxy, or substituted or unsubstituted alkylthio, * represents an asymmetric center, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.