[1-[[1-[[5-Hydroxy-4-(3-hydroxytetradecanoylamino)pentyl]amino]-1-oxo-4-phosphonooxybutan-2-yl]amino]-1-oxotetradecan-3-yl] dodecanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [1-[[1-[[5-Hydroxy-4-(3-hydroxytetradecanoylamino)pentyl]amino]-1-oxo-4-phosphonooxybutan-2-yl]amino]-1-oxotetradecan-3-yl] dodecanoate
• 化学式: C₄₉H₉₆N₃O₁₁P
• 分子量: 934.3
• InChiKey: SNSVPMFSFSJYHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.4
• 重原子数：
  64
• 可旋转键数：
  48
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  221
• 氢给体数：
  7
• 氢受体数：
  11

文献信息

• REDUCING INTERFERENCE BETWEEN OIL-CONTAINING ADJUVANTS AND SURFACTANT-CONTAINING ANTIGENS
  申请人：Novartis Vaccines and Diagnostics S.r.l.

  公开号：EP1909830B1

  公开（公告）日：2011-09-28
• Reducing interference between oil-containing adjuvants and surfactant-containing antigens
  申请人：Contorni Mario

  公开号：US20090220547A1

  公开（公告）日：2009-09-03

  Inclusion of fatty adjuvants in vaccine compositions can cause difficulties with certain antigenic components, particularly with antigens that include a surfactant component. A method for preparing an immunogenic composition comprising an antigen and a fatty adjuvant involves purification of the antigen substantially in the absence of surfactant. Where surfactants cannot be avoided, the following are combined: (i) an antigen component that includes a surfactant and (ii) a fatty adjuvant component, to give a composition in which the weight ratio of said fatty adjuvant to said surfactant is less than 1000:1.
• [EN] REDUCING INTERFERENCE BETWEEN OIL-CONTAINING ADJUVANTS AND SURFACTANT-CONTAINING ANTIGENS<br/>[FR] REDUCTION DES INTERACTIONS ENTRE ADJUVANTS HUILEUX ET ANTIGENES TENSIOACTIFS
  申请人：NOVARTIS VACCINES & DIAGNOSTIC

  公开号：WO2007015167A2

  公开（公告）日：2007-02-08

  [EN] Inclusion of fatty adjuvants in vaccine compositions can cause difficulties with certain antigenic components, particularly with antigens that include a surfactant component. A method for preparing an immunogenic composition comprising an antigen and a fatty adjuvant involves purification of the antigen substantially in the absence of surfactant. Where surfactants cannot be avoided, the following are combined: (i) an antigen component that includes a surfactant and (ii) a fatty adjuvant component, to give a composition in which the weight ratio of said fatty adjuvant to said surfactant is less than 1000:1.
  [FR] L'inclusion d'adjuvants huileux dans des compositions vaccinales peut ne pas convenir à certains composants antigènes, notamment pour des antigènes comprenant un composant tensioactifs. L'invention propose donc un procédé permettant l'élaboration d'une composition immunogène comprenant un antigène et un adjuvant gras avec purification de l'antigène sensiblement en l'absence de tout tensioactif. Lorsque le recours aux tensioactifs est inévitable, on combine (i) un composant antigène incluant un tensioactif et (ii) un adjuvant gras de façon à obtenir une composition dans le rapport massique entre l'adjuvant gras et le tensioactif est inférieur à 1000:1.