Oxynorleucine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Oxynorleucine
• 英文别名: 2-amino-2-hydroxyhexanoic acid
• 化学式: C₆H₁₃NO₃
• 分子量: 147.17
• InChiKey: OOKQATGRLIGZAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• CRISPR nanocomplex for nonviral genome editing and method for preparing the same
  申请人：KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US11319533B2

  公开（公告）日：2022-05-03

  The present invention relates to a CRISPR nanocomplex for nonviral genome editing, a method for preparing the same, and the like. The CRISPR nanocomplex for nonviral genome editing of the present invention has a size of several nanometers to several microns, enables intracellular delivery without external physical stimulation, and can be utilized for genome editing through nonviral routes with respect to target genes of cells. As a result, when used for preparation of animal model, microbiological engineering, cell engineering for disease treatment, or formulations for biological administration, the CRISPR Nanocomplex shows high intracellular delivery and gene editing efficiency, and can minimize problems, such as nonspecific editing, gene mutation, and induction of cytotoxicity and biotoxicity.

  本发明涉及一种用于非病毒基因组编辑的CRISPR纳米复合物、制备方法等。本发明的用于非病毒基因组编辑的 CRISPR 纳米复合物的尺寸为几纳米到几微米，能够在细胞内传递而无需外部物理刺激，可通过非病毒途径对细胞的靶基因进行基因组编辑。因此，当用于制备动物模型、微生物工程、用于疾病治疗的细胞工程或用于生物给药的制剂时，CRISPR 纳米复合物显示出较高的细胞内递送和基因编辑效率，并能最大限度地减少非特异性编辑、基因突变、诱导细胞毒性和生物毒性等问题。
• Genes and enzymes for the production of adipic acid intermediates
  申请人：——

  公开号：US20020127666A1

  公开（公告）日：2002-09-12

  Two gene clusters have been isolated from an Brevibacterium sp HCU that encode the enzymes expected to convert cyclohexanol to adipic acid. Individual open reading frames (ORF's) on each gene cluster are useful for the production of intermediates in the adipic acid biosynthetic pathway or of related molecules. All the ORF's have been sequenced. Identification of gene function has been made on the basis of sequence comparison and biochemical analysis.

  从一种布雷维杆菌（Brevibacterium sp HCU）中分离出了两个基因簇，它们编码将环己醇转化为己二酸的酶。每个基因簇上的单个开放阅读框（ORF）可用于生产己二酸生物合成途径中的中间产物或相关分子。所有 ORF 均已测序。根据序列比较和生化分析对基因功能进行了鉴定。
• Oxidation of a cyclohexanone derivative using a brevibacterium cyclohexanone monooxygenase
  申请人：——

  公开号：US20030113886A1

  公开（公告）日：2003-06-19

  Two gene clusters have been isolated from an Brevibacterium sp HCU that encode the enzymes expected to convert cyclohexanol to adipic acid. Individual open reading frames (ORF's) on each gene cluster are useful for the production of intermediates in the adipic acid biosynthetic pathway or of related molecules. All the ORF's have been sequenced. Identification of gene function has been made on the basis of sequence comparison and biochemical analysis.

  从一种布雷维杆菌（Brevibacterium sp HCU）中分离出了两个基因簇，它们编码将环己醇转化为己二酸的酶。每个基因簇上的单个开放阅读框（ORF）可用于生产己二酸生物合成途径中的中间产物或相关分子。所有 ORF 均已测序。根据序列比较和生化分析对基因功能进行了鉴定。
• PROCESSES AND INTERMEDIATES
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1934179A2

  公开（公告）日：2008-06-25
• CRISPR NANOCOMPLEX FOR NONVIRAL GENOME EDITING AND METHOD FOR PREPARING THE SAME
  申请人：KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20200140844A1

  公开（公告）日：2020-05-07

  The present invention relates to a CRISPR nanocomplex for nonviral genome editing, a method for preparing the same, and the like. The CRISPR nanocomplex for nonviral genome editing of the present invention has a size of several nanometers to several microns, enables intracellular delivery without external physical stimulation, and can be utilized for genome editing through nonviral routes with respect to target genes of cells. As a result, when used for preparation of animal model, microbiological engineering, cell engineering for disease treatment, or formulations for biological administration, the CRISPR Nanocomplex shows high intracellular delivery and gene editing efficiency, and can minimize problems, such as nonspecific editing, gene mutation, and induction of cytotoxicity and biotoxicity.