1-(N-Methylaminomethyl)-cyclohexanessigsaeure | 102937-74-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(N-Methylaminomethyl)-cyclohexanessigsaeure
• 英文别名: 2-[1-(Methylaminomethyl)cyclohexyl]acetic acid
• CAS: 102937-74-6
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: BPMUOFIAVBJUTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PYRIMIDINE COMPOUND
  申请人：Matsushima Yuji

  公开号：US20110053912A1

  公开（公告）日：2011-03-03

  A novel and excellent method for preventing and/or treating diseases related to a cannabinoid type 2 receptor, based on an agonistic action on a cannabinoid type 2 receptor. It was found that a hetero ring derivative mainly having two substituents, for example, a pyrimidine-5-carboxamide derivative having a substituent amino group at the 2-position, exhibits a potent agonistic action on a cannabinoid type 2 receptor, and can be an agent for preventing and/or treating diseases related to a cannabinoid type 2 receptor such as inflammatory diseases, pain, and the like.

  一种预防和/或治疗与大麻素2型受体相关疾病的新颖优秀方法，基于对大麻素2型受体的激动作用。发现一种异核环衍生物主要具有两个取代基，例如，在2-位置具有取代基氨基的嘧啶-5-羧酰胺衍生物，表现出对大麻素2型受体的强效激动作用，可以成为预防和/或治疗与大麻素2型受体相关疾病，如炎症性疾病、疼痛等的药物。
• COMPOUNDS FOR THE TREATMENT OF SEIZURES AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS AND CONDITIONS
  申请人：Ketogen Inc.

  公开号：US20150344413A1

  公开（公告）日：2015-12-03

  The present application relates to novel compounds comprising a moiety that leads to the metabolic production of ketones bonded to a ketone-potentiated anti-epileptic drug, compositions comprising these compounds, and their use, for example for the treatment of epilepsy, and other CNS diseases, disorders or conditions. In particular, the present application includes compounds of Formula I, and compositions and uses thereof:

  本申请涉及包含导致产生酮类代谢产物的基团与酮增强型抗癫痫药物结合的新化合物，包括这些化合物的组合物，以及它们的用途，例如用于治疗癫痫和其他中枢神经系统疾病、障碍或状况。具体来说，本申请包括Formula I的化合物、组合物及其用途：
• COMPOSITIONS AND METHODS FOR THE TREATMENT MIGRAINE AND NEUROLOGIC DISEASES
  申请人：KANDULA Mahesh

  公开号：US20150152060A1

  公开（公告）日：2015-06-04

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of migraine and neurologic diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, migraine, Post Herpetic Neuralgia, Acute and Chronic Pain, Alzheimer's disease, Creutzfeld Disease, familial amyloid polyneuropathy, parkinson's disease, fibromyalgia syndrome.

  本发明涉及公式I化合物或其药学上可接受的盐，以及其多晶形态、溶剂化物、对映体、立体异构体和水合物。该药物组合物包括有效量的公式I化合物，并可制成口服、颊下、直肠、局部、经皮、经黏膜、静脉、肌肉注射、糖浆或注射剂的药物制剂。这样的组合物可以用于治疗癫痫、偏头痛、带状疱疹后神经痛、急性和慢性疼痛、阿尔茨海默病、克氏肌萎缩症、家族性淀粉样多神经病、帕金森病、纤维肌痛综合征等神经系统疾病的治疗。
• COMPOUNDS AND METHODS FOR USE IN DETECTING GABAPENTIN
  申请人：Valdez Johnny Jose

  公开号：US20080199887A1

  公开（公告）日：2008-08-21

  Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A gabapentin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-gabapentin antibody. A gabapentin-detectable label may be used in a signal producing system in gabapentin assays.

  本文揭示了用于检测怀疑含有加巴喷丁的样本中的化合物和方法。使用加巴喷丁衍生物来产生加巴喷丁偶联物。加巴喷丁免疫原载体偶联物可以用作制备抗加巴喷丁抗体的免疫原。在加巴喷丁测定中，可以使用加巴喷丁可检测标签作为信号产生系统。
• BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF DIABETIC RETINOPATHY
  申请人：Warner-Lambert Company LLC

  公开号：EP1157000B1

  公开（公告）日：2005-11-02