(8E,10Z,12E)-octadeca-8,10,12-trienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (8E,10Z,12E)-octadeca-8,10,12-trienoic acid
• 化学式: C₁₈H₃₀O₂
• 分子量: 278.4
• InChiKey: DQGMPXYVZZCNDQ-NZVWDSLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] SMALL MOLECULE COMPOUNDS TO SUPPORT HEALTHY HUMAN AGING<br/>[FR] COMPOSÉS À PETITES MOLÉCULES POUR FAVORISER UN VIEILLISSEMENT HUMAIN SAIN
  申请人：CARDAX PHARMA INC

  公开号：WO2018183353A1

  公开（公告）日：2018-10-04

  Disclosed herein are methods of activating expression of the FOXO3 gene in a subject comprising administering to a subject small molecule compound (such as astaxanthin and/or one or more astaxanthin derivatives), or pharmaceutically acceptable salts thereof, in an amount sufficient to at least partially increase the amount of FoxO3 expressed in the subject.

  本文揭示了一种激活主体中FOXO3基因表达的方法，包括向主体施用小分子化合物（如虾青素和/或一个或多个虾青素衍生物）或其药用可接受盐，以足够数量至少部分增加主体中表达的FoxO3的方法。
• [EN] ANTIMICROBIAL COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS ANTIMICROBIENNES ET LEURS UTILISATIONS
  申请人：NOVUS INT INC

  公开号：WO2017004161A1

  公开（公告）日：2017-01-05

  Antimicrobial compositions comprising sulfur- or selenium-containing, fatty-acylated alpha-hydroxy acid compounds and methods of using said compounds or compositions to inhibit microbial growth.

  含有硫或硒的脂肪酰化α-羟基酸化合物的抗微生物组合物，以及使用这些化合物或组合物抑制微生物生长的方法。
• HETEROATOM CONTAINING CYCLIC DIMERS
  申请人：Novus International Inc.

  公开号：US20130209392A1

  公开（公告）日：2013-08-15

  The present invention provides cyclic dimers of alpha acids and polymers derived therefrom. Also provided are processes for preparing and methods of using the cyclic dimers and the polymers derived from the cyclic dimers.

  本发明提供了α酸的环状二聚体及其衍生物聚合物。还提供了制备环状二聚体及其衍生物聚合物的方法和使用方法。
• SYNTHESIS OF CAROTENOID ANALOGS OR DERIVATIVES WITH IMPROVED ANTIOXIDANT CHARACTERISTICS
  申请人：Foss Bente J.

  公开号：US20090099061A1

  公开（公告）日：2009-04-16

  A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.

  本文描述了一种合成和给予具有改善抗氧化特性的类胡萝卜素化合物的方法。在某些实施方式中，可以采用共轭的扩展或改进来进行类胡萝卜素的结构修饰。在其他实施方式中，降低环/链位阻可能会提高特定化合物的lambda max，从而提高其整体抗氧化能力。在其他实施方式中，引入和/或增加用于共轭的合成手柄可能会改善共轭基团与多烯骨架的化学计量比。这些方法可用于改善天然和/或合成化合物，以用于治疗疾病的医学应用。
• POLYMERIZABLE ORGANOBORON ALKYD RESIN ANTI FOULING COATINGS
  申请人：Empire Technology Development LLC

  公开号：US20140037572A1

  公开（公告）日：2014-02-06

  A compound includes a boron atom attached to at least one C 8 -C 26 fatty acid residue having at least one C═C moiety. Such compounds are polymerizable through the at least one C═C moiety. Polymers thus formed exhibit anti-fouling properties when used as coatings.

  该化合物包括一个硼原子与至少一个具有至少一个C═C官能团的C8-C26脂肪酸残基相连。这样的化合物可以通过至少一个C═C官能团进行聚合。因此形成的聚合物在用作涂层时表现出防污性能。