(S)-N2,N2,3-三甲基丁烷-1,2-二胺 | 1048692-59-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (S)-N2,N2,3-三甲基丁烷-1,2-二胺
• 英文名称: (S)-N²,N^2,3-trimethylbutane-1,2-diamine
• 英文别名: (2S)-N~2~,N~2~,3-trimethyl-1,2-butanediamine；(2S)-2-N,2-N,3-trimethylbutane-1,2-diamine
• CAS: 1048692-59-6
• 化学式: C₇H₁₈N₂
• 分子量: 130.233
• InChiKey: DJVWTEQJNMZOQF-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-N2,N2,3-三甲基丁烷-1,2-二胺 、 N-[(1R,2R)-2-异硫氰基环己基]氨基甲酸叔丁酯 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 tert-butyl ((1R,2R)-2-(3-((S)-2-(dimethylamino)-3-methylbutyl)thioureido)cyclohexyl)carbamate
  参考文献：
  名称：

  Target-oriented multifunctional organocatalysis for enantioselective synthesis of bicyclo[3.3.1]nona-2,6-dien-9-ones. A formal asymmetric synthesis of huperzine A

  摘要：

  A target-oriented highly enantioselective multifunctional organocatalytic approach has been developed to construct the bicycle-[3.3.1]nona-2,6-dien-9-one core of (-)-huperzine A for the first time, with up to 95% ee in the gram-scale procedure. The newly established methodology is also eligible to synthesize a variety of bicyclo[3.3.1]nona-2,6-dien-9-ones in high enantiopurities, and thus is useful for the future development of novel huperzine A analogs with medicinal interests. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.05.061
• 作为产物：
  描述：

  (S)-2-(dimethylamino)-3-methylbutanamide 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 以69%的产率得到(S)-N2,N2,3-三甲基丁烷-1,2-二胺
  参考文献：
  名称：

  新型双官能手性尿素和硫脲衍生物作为有机催化剂：丙二酸酯和二酮的对映选择性硝基-迈克尔反应。

  摘要：

  DOI：

  10.1002/chem.200800633

文献信息

• Novel Bifunctional Chiral Urea and Thiourea Derivatives as Organocatalysts: Enantioselective Nitro-Michael Reaction of Malonates and Diketones
  作者：José M. Andrés、Rubén Manzano、Rafael Pedrosa

  DOI：10.1002/chem.200800633

  日期：2008.6.9
• Target-oriented multifunctional organocatalysis for enantioselective synthesis of bicyclo[3.3.1]nona-2,6-dien-9-ones. A formal asymmetric synthesis of huperzine A
  作者：Xiao-Hua Ding、Xiang Li、Dan Liu、Wei-Chen Cui、Xuan Ju、Shaozhong Wang、Zhu-Jun Yao

  DOI：10.1016/j.tet.2012.05.061

  日期：2012.8

  A target-oriented highly enantioselective multifunctional organocatalytic approach has been developed to construct the bicycle-[3.3.1]nona-2,6-dien-9-one core of (-)-huperzine A for the first time, with up to 95% ee in the gram-scale procedure. The newly established methodology is also eligible to synthesize a variety of bicyclo[3.3.1]nona-2,6-dien-9-ones in high enantiopurities, and thus is useful for the future development of novel huperzine A analogs with medicinal interests. (C) 2012 Elsevier Ltd. All rights reserved.