L-335677

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: L-335677
• 英文别名: 2-(3-{3-[5-chloro-2-(phenylmethoxy)phenyl]-2-thienyl}-phenyl)acetic acid；{3-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-phenyl}-acetic acid；2-[3-[3-(5-chloro-2-phenylmethoxyphenyl)thiophen-2-yl]phenyl]acetic acid
• 化学式: C₂₅H₁₉ClO₃S
• 分子量: 434.943
• InChiKey: PNVFGVWWQZJNKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  74.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method of treating or preventing urinary incontinence using prostanoid EP1 receptor antagonists
  申请人：——

  公开号：US20020137746A1

  公开（公告）日：2002-09-26

  This invention encompasses a method of treating or preventing urinary incontinence in a mammalian patient comprising administering to the patient a compound of formula I: 1 or a pharmaceutically acceptable salt, hydrate or ester thereof. The invention also encompasses certain pharmaceutical compositions and methods for treatment of prostaglandin mediated diseases comprising the use of compounds of formula I.

  这项发明涵盖了一种治疗或预防哺乳动物患者尿失禁的方法，包括向患者施用式I的化合物：1或其药学上可接受的盐、水合物或酯。该发明还涵盖了某些药物组合物和治疗前列腺素介导疾病的方法，包括使用式I的化合物。
• BENZOXAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND HERBICIDES
  申请人：Ube Industries, Ltd.

  公开号：EP1180515A1

  公开（公告）日：2002-02-20

  The present invention relates to a benzoxazole compound represented by the following formula (1):    wherein R1 to R4 each represents hydrogen atom, C1-6 alkyl group, C1-4 alkoxy group, C1-4 haloalkyl group, C1-4 haloalkoxy group, halogen atom, nitro group, cyano group, etc.; R5 represents C1-4 haloalkyl group, C1-4 haloalkoxy group, halogen atom, nitro group, cyano group, etc.; R6 represents hydrogen atom, halogen atom, cyano group, nitro group, etc.; R7 represents hydrogen atom, C1-6 alkyl group, C1-4 haloalkyl group, etc.; and X represents O, S, SO or SO2, a process for producing the same and a herbicide containing the same as an effective ingredient.

  本发明涉及由下式(1)代表的苯并恶唑化合物： 其中R1至R4各自代表氢原子、C1-6烷基、C1-4烷氧基、C1-4卤代烷基、C1-4卤代烷氧基、卤素原子、硝基、氰基等；R5代表C1-4卤代烷基、C1-4卤代烷氧基、卤素原子、硝基、氰基等。R6 代表氢原子、卤素原子、氰基、硝基等；R7 代表氢原子、C1-6 烷基、C1-4 卤代烷基等；X 代表 O、S、SO 或 SO2、 生产上述物质的工艺以及含有上述物质作为有效成分的除草剂。
• CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：MERCK FROSST CANADA & CO.

  公开号：EP1216238B1

  公开（公告）日：2004-02-18
• US6369084B1
  申请人：——

  公开号：US6369084B1

  公开（公告）日：2002-04-09
• [EN] CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT<br/>[FR] ACIDES CARBOXYLIQUES ET ACYLSULFONAMIDES, COMPOSITIONS CONTENANT DE TELS COMPOSES ET METHODES DE TRAITEMENT
  申请人：MERCK FROSST CANADA INC

  公开号：WO2001019814A2

  公开（公告）日：2001-03-22

  This invention encompasses the novel compounds of formula (A), which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester thereof. The invention also encompasses certain pharmaceutical compositions and methods for treatment of prostaglandin mediated diseases comprising the use of compounds of formula (A).