(+/-)-5-[[4-[2-Methyl-(2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidine-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (+/-)-5-[[4-[2-Methyl-(2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidine-dione
• 英文别名: 5-[[4-[2-(pyridin-2-ylamino)propoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• 化学式: C₁₈H₁₉N₃O₃S
• 分子量: 357.4
• InChiKey: GBKSOHUCUJBEPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Synergistic combination comprising an insulin sensitizer and a HMG-CoA reductase inhibitor for treating arteriosclerosis
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0753298A1

  公开（公告）日：1997-01-15

  A combination of one or more HMG-CoA reductase inhibitors (for example pravastatin, lovastatin, simvastatin, fluvastatin, rivastatin or atorvastatin) with one or more insulin sensitizers (for example troglitazone, pioglitazone, englitazone, BRL-49653, 5-(4-2-[1-(4-2'-pyridylphenyl)ethylideneaminooxy]-ethoxy}benzyl}thiazolidine-2,4-dione, 5-4-(5-methoxy-3-methylimidazo[5,4-b]pyridin-2-yl-methoxy)benzyl}thiazolidine-2,4-dione or its hydrochloride, 5-[4-(6-methoxy-1-methylbenzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione, 5-[4-(1-methylbenzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione and 5-[4-(5-hydroxy-1,4,6,7-tetramethylbenzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione) exhibits a synergistic effect and is significantly better at preventing and/or treating arteriosclerosis and/or xanthoma than is either of the components of the combination alone.

  一种或多种 HMG-CoA 还原酶抑制剂（例如普伐他汀、洛伐他汀、辛伐他汀、氟伐他汀、利伐他汀或阿托伐他汀）与一种或多种胰岛素增敏剂（例如曲格列 酮、吡格列酮、英格列酮、BRL-49653、5-(4-2-[1-(4-2'-吡啶基苯基)亚乙基氨基氧基]-乙氧基}苄基）的复方制剂、恩格列酮、BRL-49653、5-(4-2-[1-(4-2'-吡啶基苯基)亚乙基氨基氧基]-乙氧基}苄基}噻唑烷-2,4-二酮、5-4-(5-甲氧基-3-甲基咪唑并[5,4-b]吡啶-2-基-甲氧基)苄基}噻唑烷-2,4-二酮或其盐酸盐、5-[4-(6-甲氧基-1-甲基苯并咪唑-2-基甲氧基)苄基]噻唑烷-2,4-二酮、5-[4-(1-甲基苯并咪唑-2-基甲氧基)苄基]噻唑烷-2,4-二酮和 5-[4-(5-羟基-1,4,6,7-四甲基苯并咪唑-2-基甲氧基)苄基]噻唑烷-2、4-二酮）产生协同效应，在预防和/或治疗动脉硬化和/或黄疽方面的效果明显优于单独使用组合中的任何一种成分。
• US6159997A
  申请人：——

  公开号：US6159997A

  公开（公告）日：2000-12-12