申请人:TERUMO KABUSHIKI KAISHA
公开号:US10188774B2
公开(公告)日:2019-01-29
Provided is a method for producing an antithrombotic coating material in which a high molecular weight polymer can be obtained by a solution polymerization using a radical polymerization initiator. The above-mentioned task is achieved by a method for producing an antithrombotic coating material, including steps of: preparing a methanol solution containing a monomer represented by formula (1):
wherein in formula (1), R1, R2, and R3 are the same as those described in the specification, respectively; adding a radical polymerization initiator having a 10-hour half-life temperature of 60° C. or less to the methanol solution to prepare a polymerization reaction liquid; and polymerizing the monomer.
本发明提供了一种生产抗血栓涂层材料的方法,在该方法中,使用自由基聚合引发剂通过溶液聚合可以获得高分子量聚合物。上述任务是通过生产抗血栓涂层材料的方法实现的,该方法包括以下步骤:制备含有式(1)所代表单体的甲醇溶液:
其中,式(1)中的 R1、R2 和 R3 分别与说明书中所述的相同;向甲醇溶液中加入半衰期为 10 小时、温度不超过 60 摄氏度的自由基聚合引发剂,制备聚合反应液;聚合单体。