Nitrosotyrosine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Nitrosotyrosine
• 英文别名: (2S)-3-(4-hydroxyphenyl)-2-(2-oxohydrazinyl)propanoic acid
• 化学式: C₉H₁₀N₂O₄
• 分子量: 210.19
• InChiKey: NGWWJSVRCMRJJM-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  99
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality
  申请人：——

  公开号：US20030007967A1

  公开（公告）日：2003-01-09

  Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body. The invention also relates to the nitrosylation of oxygen, carbon and nitrogen moieties present on proteins and amino acids, and the use thereof to achieve the above physiological effects.

  蛋白质和氨基酸基团的亚硝酰化使得蛋白质功能可以有选择性地调节，并且赋予蛋白质和氨基酸额外的平滑肌松弛和血小板抑制能力。因此，本发明涉及通过蛋白质巯基的亚硝酰化而获得的新化合物。这些化合物包括：S-亚硝基-t-PA、S-亚硝基-卡特普西林、S-亚硝基-脂蛋白和S-亚硝基-免疫球蛋白。本发明还涉及将S-亚硝基蛋白质化合物用于调节蛋白质功能、细胞代谢和实现血管扩张、血小板抑制、非血管平滑肌松弛以及通过血红蛋白和肌红蛋白增加血氧输送的治疗用途。这些化合物也用于以其最活性的形式释放一氧化氮，以实现上述效果，或用于体外亚硝酰化体内分子。本发明还涉及蛋白质和氨基酸上存在的氧、碳和氮官能团的亚硝酰化及其用于实现上述生理效应。
• Nitrosated and nitrosylated heme proteins
  申请人：——

  公开号：US20030211977A1

  公开（公告）日：2003-11-13

  Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-heme proteins, S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoproteins; and S-nitroso-immunoglobulins. The invention also relates to therapeutic use if S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body. The invention also relates to the nitrosylation of oxygen, carbon and nitrogen moieties present on proteins and amino acids, and the use thereof to achieve the above physiological effects.

  蛋白质和氨基酸基团的亚硝酰化使蛋白质功能得以选择性调节，并赋予其额外的平滑肌松弛和血小板抑制能力。因此，本发明涉及通过蛋白质巯基的亚硝酰化而实现的新化合物。这些化合物包括：S-亚硝基血红蛋白蛋白，S-亚硝基-t-PA，S-亚硝基卡特普汀；S-亚硝基脂蛋白；和S-亚硝基免疫球蛋白。本发明还涉及利用S-亚硝基蛋白化合物治疗调节蛋白质功能，细胞代谢和实现血管扩张，血小板抑制，非血管平滑肌松弛和血红蛋白和肌红蛋白增加血氧输送的用途。这些化合物也用于以其最生物活性形式释放一氧化氮，以实现上述效果，或用于体外亚硝酰化体内分子。本发明还涉及蛋白质和氨基酸上存在的氧，碳和氮基团的亚硝酰化及其用于实现上述生理效应。
• Pharmaceutical composition containing S-nitroso-immunoglobulins and use thereof
  申请人：BRIGHAM AND WOMEN'S HOSPITAL

  公开号：EP1023905A2

  公开（公告）日：2000-08-02

  The invention relates to the therapeutic use of S-nitroso-immunoglobulin for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle and to deliver nitric oxide in its most bioactive form in order to achieve the effects described above.

  本发明涉及 S-亚硝基免疫球蛋白的治疗用途，用于调节蛋白质功能、细胞新陈代谢并起到扩张血管、抑制血小板、松弛非血管平滑肌的作用，并以最具生物活性的形式输送一氧化氮，以达到上述效果。
• Pharmaceutical composition containing S-nitroso-heme proteins and use thereof
  申请人：BRIGHAM AND WOMEN'S HOSPITAL

  公开号：EP1025853A2

  公开（公告）日：2000-08-09

  The invention relates to the therapeutic use of S-nitroso-heme protein for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle and to deliver nitric oxide in its most bioactive form in order to achieve the effects described above.

  本发明涉及 S-亚硝基血红素蛋白的治疗用途，用于调节蛋白质功能、细胞新陈代谢，并起到扩张血管、抑制血小板、松弛非血管平滑肌的作用，并以最具生物活性的形式输送一氧化氮，以达到上述效果。
• Tau-binding antibodies
  申请人：UCB BIOPHARMA SPRL

  公开号：US10344081B2

  公开（公告）日：2019-07-09

  The present invention relates to Tau-binding antibodies and binding fragments thereof.

  本发明涉及 Tau 结合抗体及其结合片段。