14-Hydroxy-11-eicosenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 14-Hydroxy-11-eicosenoic acid
• 英文别名: (E)-14-hydroxyicos-11-enoic acid
• 化学式: C₂₀H₃₈O₃
• 分子量: 326.5
• InChiKey: OONXYOAWMIVMCI-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  23
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHOD FOR THE SYNTHESIS OF DIACIDS OR DIESTERS FROM NATURAL FATTY ACIDS AND/OR ESTERS
  申请人：Dubois Jean-Luc

  公开号：US20100305354A1

  公开（公告）日：2010-12-02

  The invention relates to a process for the synthesis of diacids or diesters of general formula ROOC—(CH 2 ) x —COOR, in which n is an integer between 5 and 14, R is either H or an alkyl radical of 1 to 4 carbon atoms, from natural long-chain monounsaturated fatty acids or esters including at least 10 adjacent carbon atoms per molecule of the general formula CH 3 —(CH 2 ) n —CHR 1 —CH 2 —CH═CH—(CH 2 ) p —COOR, in which R is H or an alkyl radical with 1 to 4 carbon atoms, R 1 is either H or OH, and n and p, which are equal or different and are indices between 2 and 11. The method comprises: during a first step, converting the natural fatty acid or ester by pyrolysis or by ethenolysis, into a ω-monounsaturated fatty acid or ester of the general formula CH 2 ═CH—(CH 2 ) m —COOR, in which m is equal to p or p+1, depending on the nature of the processed fatty acid/ester and the conversion used; during a second step, submitting the product thus obtained to a metathesis or homometathesis reaction for obtaining a compound of the general formula ROOC—(CH 2 ) m —CH═CH—(CH 2 ) m —COOR, or cross-metathesis with a compound of formula R 2 OOC—(CH 2 ) r —CH═CH—R 3 , in which R 2 is either H or an alkyl radical front with 1 to 4 carbon atoms, r is either 0 or 1 or 2 and R 3 is H, CH 3 or COOR 2 , thus defining a cyclic or molecule or not, in order to obtain an unsaturated compound of the general formula ROOC—(CH 2 ) m —CH═CH—(CH 2 ) r —COOR 2 , and during a third step, converting the unsaturated compound into a saturated compound by hydrogenation of the double bond.

  这项发明涉及一种合成一般公式为ROOC—(CH2)x—COOR的二元酸或二元酯的过程，其中n是5到14之间的整数，R是H或1到4个碳原子的烷基自由基，从天然长链单不饱和脂肪酸或酯中合成，这些脂肪酸或酯每分子至少包括10个相邻的碳原子，其一般公式为CH3—( )n—CHR1— —CH═CH—( )p—COOR，其中R是H或1到4个碳原子的烷基自由基，R1是H或OH，n和p相等或不同，是2到11之间的指数。该方法包括：在第一步中，通过热解或乙炔醇解将天然脂肪酸或酯转化为ω-单不饱和脂肪酸或酯，其一般公式为 ═CH—( )m—COOR，其中m等于p或p+1，具体取决于处理的脂肪酸/酯的性质和所使用的转化；在第二步中，将所得产物进行交叉代谢或同交叉代谢反应，以获得一般公式为ROOC—( )m—CH═CH—( )m—COOR的化合物，或与公式为R2OOC—( )r—CH═CH—R3的化合物进行交叉代谢，其中R2是H或1到4个碳原子的烷基自由基，r是0或1或2，R3是H、 或COOR2，从而定义一个循环或不循环的分子，以获得一般公式为ROOC—( )m—CH═CH—( )r—COOR2的不饱和化合物；在第三步中，通过加氢双键将不饱和化合物转化为饱和化合物。
• BIOPASSIVATING MEMBRANE STABILIZATION BY MEANS OF NITROCARBOXYLIC ACID-CONTAINING PHOSPHOLIPIDS IN PREPARATIONS AND COATINGS
  申请人：Dietz Ulrich

  公开号：US20140099354A1

  公开（公告）日：2014-04-10

  The present invention relates to nitro-carboxylic acid (s)-containing phospholipids, to be used for coating of medical devices such as stents, catheter balloons, wound pads or surgical suture material and for bio-passivating compositions, such as rinses, waterproofing solutions, coating solutions, cryoprotection solutions, cold preservation media, lyoprotection solutions, contrast media solutions, preservation and reperfusion solutions containing these compounds as well as preparing solutions thereof and coating medical devices as well as their uses.

  本发明涉及一种含硝基羧酸（s）的磷脂，用于涂覆医疗器械，如支架、导管球囊、伤口垫或外科缝合材料，以及用于生物钝化组合物，如漱口液、防水溶液、涂层溶液、冷冻保护溶液、冷藏介质、冻干保护溶液、造影介质溶液、含有这些化合物的保存和再灌注溶液，以及制备这些溶液和涂覆医疗器械以及它们的用途。
• Process for Producing Nitrile-Fatty Acid Compounds
  申请人：Brandhorst Markus

  公开号：US20130345388A1

  公开（公告）日：2013-12-26

  The invention relates to a process for synthesizing a nitrile-fatty acid (heminitrile) from unsaturated fatty acids, in the form of an acid or a simple ester or a “complex” ester of triglyceride type, which is first of all converted into an unsaturated fatty nitrile which is subjected to oxidative cleavage using H 2 O 2 as oxidizing agent. This process can be used for preparing polyamide monomers, such as ω-amino acids or diamines or diacids equivalent to said heminitrile and for obtaining polyamides from raw materials which are of natural origin and from a renewable source.

  该发明涉及一种从不饱和脂肪酸合成一种腈基脂肪酸（半腈）的方法，该脂肪酸以酸或简单酯或三酸甘油酯型“复合”酯的形式存在，首先转化为不饱和脂肪腈，然后使用H2O2作为氧化剂进行氧化裂解。该方法可用于制备聚酰胺单体，如ω-氨基酸或二胺或与所述半腈等效的二酸，并从天然来源和可再生来源的原材料获得聚酰胺。
• METHOD FOR THE COPRODUCTION OF METHYL 7-OXOHEPTANOATE AND UNDECYLENIC ACID FROM RICINOLEIC ACID
  申请人：Dubois Jean-Luc

  公开号：US20100203600A1

  公开（公告）日：2010-08-12

  The invention relates to a method for converting ricinoleic acid that comprises the following successive stages: a) fermentation of ricinoleic acid by a bacterium, a yeast or a fungus, in order to obtain 7-hydroxy-9-octadecenedioic diacid, b) the esterification of the 7-hydroxy-9-octadecenedioic diacid obtained in-stage during step a), in order to form the corresponding methyl diester, c) high-temperature cracking of the product obtained during step b), in order to form a mixture of methyl undecylenate and methyl 7-oxoheptanoate, d) separating the methyl undecylenate and methyl 7-oxoheptanoate obtained in step c), e) hydrolysing the methyl undecylenate obtained in step d), for forming the undecylenic acid.

  本发明涉及一种转化蓖麻油酸的方法，包括以下连续阶段：a）通过细菌、酵母或真菌发酵蓖麻油酸，以获得7-羟基-9-十八烯二酸，b）在步骤a)中获得的7-羟基-9-十八烯二酸酯化，形成相应的甲基双酯，c）高温裂解步骤b)中获得的产物，形成甲基十一烯酸甲酯和甲基7-氧代庚酸甲酯的混合物，d）分离步骤c)中获得的甲基十一烯酸甲酯和甲基7-氧代庚酸甲酯，e）水解步骤d)中获得的甲基十一烯酸甲酯，形成十一烯酸。
• NANO-SIZED PARTICLES COMPRISING MULTI-HEADED AMPHIPHILES FOR TARGETED DRUG DELIVERY
  申请人：Linder Charles

  公开号：US20120164072A1

  公开（公告）日：2012-06-28

  Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.

  提供了一种纳米级颗粒，其中包含至少一种多头亲疏水化合物，其中至少一个头基团是可选择性断裂的或含有可选择性断裂基团，并且至少一种生物活性剂被封装在纳米粒子内并与其非共价结合。