(2R)-2-(cyclopentylmethyl)-3-[formyl(hydroxy)amino]-N-[(6-methyl-1H-benzimidazol-2-yl)methyl]propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-(cyclopentylmethyl)-3-[formyl(hydroxy)amino]-N-[(6-methyl-1H-benzimidazol-2-yl)methyl]propanamide
• 化学式: C₁₉H₂₆N₄O₃
• 分子量: 358.4
• InChiKey: FBWPDGSFCRSBOQ-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  98.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Hydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections
  申请人：——

  公开号：US20040106666A1

  公开（公告）日：2004-06-03

  1 Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula —N(OH)CH(═O) or formula C(═O)NH(OH); R 1 represents hydrogen, methyl or trifluromethyl, or except when Z is a radical of formula —N(OH)(═O), a hydroxy, halo or am group; R 2 represents a group R 10 —(X) n -(ALK) m — wherein R 10 , ALK, X, m and n are as defined in the specification; R 3 represents hydrogen, (C 1 -C 6 ) alkyl or phenyl(C 1 -C 6 )alkyl-; and R 5 and R 6 are as defined in the specification.

  公式（I）的化合物是用于治疗人类和非人哺乳动物感染的抗菌或抗原虫药物，其中：Z代表公式—N（OH）CH（═O）或公式C(═O)NH(OH)的基团；R1代表氢、甲基或三氟甲基，或者除非Z是公式—N(OH)(═O)的基团，否则是一个羟基、卤素或氨基；R2代表一个基团R10—(X)n-(ALK)m—，其中R10、ALK、X、m和n如规范中所定义；R3代表氢、（C1-C6）烷基或苯基（C1-C6）烷基；R5和R6如规范中所定义。
• N-FORMYL HYDROXYLAMINE DERIVATIVES AS INHIBITORS OF BACTERIAL POLYPEPTIDE DEFORMYLASE FOR TREATING MICROBIAL INFECTIONS
  申请人：Vernalis (Oxford) Ltd

  公开号：EP1339400B1

  公开（公告）日：2005-06-29
• N-FORMYL HYDROXYLAMINE DERIVATIVES AS INHIBITORS OF BACTERIAL POLYPEPTIDE FORMYLASE FOR TREATING MICROBIAL INFECTIONS
  申请人：Beckett Paul Raymond

  公开号：US20090069322A1

  公开（公告）日：2009-03-12

  Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula —N(OH)CH(═O) or formula C(═O)NH(OH); R 1 represents hydrogen, methyl or trifluoromethyl, or except when Z is a radical of formula —N(OH)CH(═O), a hydroxy, halo or amino group; R 2 represents a group R 10 —(X) n -(ALK) m — wherein R 10 , ALK, X, m and n are as defined in the specification; R 3 represents hydrogen, (C 1 -C 6 ) alkyl or phenyl(C 1 -C 6 )alkyl-; and R 5 and R 6 are as defined in the specification.
• US7173053B2
  申请人：——

  公开号：US7173053B2

  公开（公告）日：2007-02-06