(环己基氨基)(苯基)乙酸甲酯 | 78907-07-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (环己基氨基)(苯基)乙酸甲酯
• 英文名称: methyl 2-(cyclohexylamino)-2-phenylacetate
• 英文别名: Methyl (cyclohexylamino)(phenyl)acetate
• CAS: 78907-07-0
• 化学式: C₁₅H₂₁NO₂
• mdl: MFCD03075548
• 分子量: 247.337
• InChiKey: GIERMKQJVHUGLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.533
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

上下游信息

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  ——	(cyclohexylamino)(phenyl)acetic acid	39640-74-9	C14H19NO2	233.31
  2-[环己基-(2-苯基乙酰基)氨基]-2-苯基-乙酸甲酯	(Cyclohexyl-phenylacetyl-amino)-phenyl-acetic acid methyl ester	83529-26-4	C23H27NO3	365.472

反应信息

• 作为反应物：
  描述：

  (环己基氨基)(苯基)乙酸甲酯 以50%的产率得到
  参考文献：
  名称：

  DAVTYAN S. M.; PAPAYAN G. L.; MELKONYAN D. A., AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH., 1981, 34, HO 4, 339-341

  摘要：

  DOI：
• 作为产物：
  描述：

  α-溴苯乙酸甲酯 、 环己胺 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 4.0h， 生成 (环己基氨基)(苯基)乙酸甲酯
  参考文献：
  名称：

  Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators

  摘要：

  Design, synthesis and structure-activity relationships of beU:/AP/DTD501/BMC/4818nzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper. AMPK is the central component of a protein kinase cascade that plays a key role in the regulation of energy balance. Once activated, AMPK initiates a series of responses that are aimed at restoring the energy balance of the cell and recent studies have indicated that AMPK plays an important role in regulation of the whole-body energy metabolism. The following study based on the lead compound S27847 involved modification of three regions of this compound. Preliminary structure activity relationships are being described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.02.028

文献信息

• Copper-Catalyzed Amination of Silyl Ketene Acetals with <i>N</i>-Chloroamines
  作者：Tomoya Miura、Masao Morimoto、Masahiro Murakami

  DOI：10.1021/ol302331k

  日期：2012.10.19

  A copper(I)/2,2′-bipyridyl complex catalyzes an amination reaction of silyl ketene acetals with N-chloroamines, presenting a new preparative method of α-amino esters.

  铜（I）/ 2,2'-联吡啶配合物催化甲硅烷基乙烯酮缩醛与N-氯胺的胺化反应，为α-氨基酯的制备提供了一种新的方法。
• Derivatives of aminophenylacetic acid and their antineoplastic activity
  作者：S. M. Davtyan、G. L. Papayan、A. A. Chachoyan、K. G. Samvelyan

  DOI：10.1007/bf00761542

  日期：1982.7
• DAVTYAN, S. M.;PAPAYAN, G. L.;CHACHOYAN, A. A.;SAMVELYAN, K. G., XIM.-FARMATS. ZH., 1982, 16, N 7, 794-796
  作者：DAVTYAN, S. M.、PAPAYAN, G. L.、CHACHOYAN, A. A.、SAMVELYAN, K. G.

  DOI：——

  日期：——
• Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators
  作者：Julie Charton、Sophie Girault-Mizzi、Marie-Ange Debreu-Fontaine、Fabienne Foufelle、Isabelle Hainault、Jean-Guy Bizot-Espiard、Daniel-Henri Caignard、Christian Sergheraert

  DOI：10.1016/j.bmc.2006.02.028

  日期：2006.7

  Design, synthesis and structure-activity relationships of beU:/AP/DTD501/BMC/4818nzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper. AMPK is the central component of a protein kinase cascade that plays a key role in the regulation of energy balance. Once activated, AMPK initiates a series of responses that are aimed at restoring the energy balance of the cell and recent studies have indicated that AMPK plays an important role in regulation of the whole-body energy metabolism. The following study based on the lead compound S27847 involved modification of three regions of this compound. Preliminary structure activity relationships are being described. (c) 2006 Elsevier Ltd. All rights reserved.
• DAVTYAN S. M.; PAPAYAN G. L.; MELKONYAN D. A., AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH., 1981, 34, HO 4, 339-341
  作者：DAVTYAN S. M.、 PAPAYAN G. L.、 MELKONYAN D. A.

  DOI：——

  日期：——