2-Amino-3-[4-(2-bromoethoxy)phenyl]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-3-[4-(2-bromoethoxy)phenyl]propanoic acid
• 化学式: C₁₁H₁₄BrNO₃
• 分子量: 288.14
• InChiKey: OSYXBYWFALZNNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Methods and compositions for ribosomal synthesis of macrocyclic peptides
  申请人：University of Rochester

  公开号：US10544191B2

  公开（公告）日：2020-01-28

  Methods and compositions are provided for generating macrocyclic peptides from genetically encoded, ribosomally produced polypeptide precursors. Also provided are nucleic acid molecules, polypeptides, and methods for generating combinatorial libraries of macrocyclic peptides. These methods can be used to produce vast libraries of conformationally constrained peptide ligands as well as facilitate the functional screening of these libraries to identify compound(s) with desired activity properties.

  提供了从基因编码、核糖体产生的多肽前体生成大环肽的方法和组合物。还提供了核酸分子、多肽和生成大环肽组合库的方法。这些方法可用于产生大量的构象受限多肽配体库，以及促进这些库的功能筛选，以确定具有所需活性特性的化合物。
• [EN] METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA SYNTHÈSE RIBOSOMIQUE DE PEPTIDES MACROCYCLIQUES
  申请人：UNIV ROCHESTER

  公开号：WO2015100277A9

  公开（公告）日：2015-10-01
• METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES
  申请人：University Of Rochester

  公开号：EP3087088A2

  公开（公告）日：2016-11-02
• Methods and Compositions for Display of Macrocyclic Peptides
  申请人：University of Rochester

  公开号：US20200299675A1

  公开（公告）日：2020-09-24

  Methods and compositions are provided for the display of genetically encoded macrocyclic peptides on a biological surface. Also provided are nucleic acid molecules, polypeptides, and methods for generating combinatorial libraries of macrocyclic peptides displayed on a biological surface. These methods can be used to produce and screen vast libraries of conformationally constrained peptides in a high-throuput manner, from which macrocyclic peptides with a desired property can be selected and identified.