2-cyclopentyl-N-(1-ethyl-5,5-dimethyl-2-oxo-3,4-dihydro-1-benzazepin-3-yl)acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-cyclopentyl-N-(1-ethyl-5,5-dimethyl-2-oxo-3,4-dihydro-1-benzazepin-3-yl)acetamide
• 化学式: C₂₁H₃₀N₂O₂
• 分子量: 342.5
• InChiKey: OPMZZCAGMVCMHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Wu Jing

  公开号：US20050272666A1

  公开（公告）日：2005-12-08

  Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及一种抑制β-淀粉样肽释放和/或其合成的化合物，因此在治疗阿尔茨海默病方面具有用途。同时，本发明还涉及包括抑制β-淀粉样肽释放和/或其合成的化合物的制药组合物，以及使用这些制药组合物预防和治疗阿尔茨海默病的方法。