3-hexyl-4-[(4E,7E)-2-hydroxytrideca-4,7-dienyl]oxetan-2-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-hexyl-4-[(4E,7E)-2-hydroxytrideca-4,7-dienyl]oxetan-2-one
• 化学式: C₂₂H₃₈O₃
• 分子量: 350.5
• InChiKey: AAWOMKPGDBROBM-IWCZYTNJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  25
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• N-acyl modified polysaccharides and pharmaceutical compositions comprising same
  申请人：Gentry Mullins Jason John

  公开号：US20060046974A1

  公开（公告）日：2006-03-02

  This invention relates to novel N-acyl modified polysaccharides and pharmaceutical compositions comprising the modified polysaccharides. Further the invention relates to processes for using such compounds to inhibit lipases, to lower cholesterol, to lower the absorption of dietary fat, or as a dietary fiber supplement. In a preferred aspect of the invention the modified polysaccharides are capable of absorbing substantial amounts of oils or fats while dissipating in an aqueous solution. The invention also relates to a non-absorbable and essentially non-digestible polysaccharide fiber composition.

  本发明涉及新型的N-酰基修饰多糖和包含修饰多糖的药物组合物。此外，本发明还涉及使用这些化合物抑制脂肪酶、降低胆固醇、降低膳食脂肪吸收或作为膳食纤维补充剂的方法。在本发明的一个优选方面，修饰多糖能够吸收大量油脂，同时在水溶液中消散。本发明还涉及一种不可吸收且基本上不可消化的多糖纤维组合物。
• Oxetanone derivatives
  申请人：——

  公开号：US20010012852A1

  公开（公告）日：2001-08-09

  This invention relates to novel oxetanone derivative compounds and processes for producing such derivatives that are useful as lipase inhibitors. Further the invention relates to processes for producing salts and for producing pharmaceutical compositions compounds comprising at least one such oxetanone derivative or salt, as well as methods for using such compounds and compositions for inhibiting lipases.

  本发明涉及新型氧杂环丁酮衍生物化合物和生产可用作脂肪酶抑制剂的此类衍生物的工艺。此外，本发明还涉及生产包含至少一种此类氧杂环丁酮衍生物或盐的盐的工艺和生产包含至少一种此类氧杂环丁酮衍生物或盐的药物组合物的工艺，以及使用此类化合物和组合物抑制脂肪酶的方法。
• Method and composition for reducing sebum secretion in mammals
  申请人：——

  公开号：US20030054020A1

  公开（公告）日：2003-03-20

  This invention relates to reducing sebum production on the skin using methods and compositions containing a surfactant, a chylomicron disrupter, a skin penetration enhancer, and an anti-androgenic compound. In a preferred embodiment, the composition contains the surfactant as a mixture of polyoxyethylene compounds and the anti-androgenic agent as a mixture of saw palmetto extract and nettle extract.

  本发明涉及使用含有表面活性剂、乳糜微粒干扰物、皮肤渗透促进剂和抗雄激素化合物的方法和组合物减少皮肤皮脂分泌。在一个优选的实施方案中，组合物中的表面活性剂是聚氧乙烯化合物的混合物，抗雄激素剂是锯棕榈提取物和荨麻提取物的混合物。
• N-acyl modified polysaccharides and pharmaceutical compositions comprising same and dietary calcium
  申请人：Mullins Jason Gentry John

  公开号：US20060052339A1

  公开（公告）日：2006-03-09

  This invention relates to novel N-acyl modified polysaccharides and pharmaceutical compositions comprising the modified polysaccharides and comprising dietary calcium as a mixture or as a salt. Further the invention relates to processes for using such compounds to inhibit lipases, to lower cholesterol, to lower the absorption of dietary fat, or as a dietary fiber supplement. In a preferred aspect of the invention the modified polysaccharides are capable of absorbing substantial amounts of oils or fats while dissipating in an aqueous solution. The invention also relates to a non-absorbable and essentially non-digestible polysaccharide fiber composition that is useful as a weight loss composition.

  本发明涉及新型 N-酰基改性多糖以及包含改性多糖和膳食钙混合物或盐的药物组合物。此外，本发明还涉及使用此类化合物抑制脂肪酶、降低胆固醇、降低膳食脂肪吸收或作为膳食纤维补充剂的工艺。在本发明的一个优选方面，改性多糖能够吸收大量的油脂，同时在水溶液中消散。本发明还涉及一种不可吸收且基本不消化的多糖纤维组合物，可用作减肥组合物。
• N-Acyl and quaternary ammonium modified polysaccharide fibers
  申请人：Gentry Mullins Jason John

  公开号：US20060052338A1

  公开（公告）日：2006-03-09

  This invention relates to novel N-Acyl and N-Alkyl modified quaternary ammonium polysaccharide fibers, or both N-Acyl and N-Alkyl modified quaternary ammonium polysaccharide fibers and pharmaceutical compositions comprising the modified fibers. Further the invention relates to processes for using such modified polysaccharide fibers to lower cholesterol, to lower a mammal's absorption and metabolic use of dietary fat as calories, or as a dietary fiber supplement. The polysaccharides may be modified with quaternary ammonium side chains that are capable of sequestering bile salts while other portions of the polysaccharide absorbs substantial amounts of oils or fats while dissipating the modified polysaccharide and oil complex in aqueous digestive fluids and solids. The N-Acyl modified polysaccharide intermediates are also useful to lower cholesterol, lower the absorption and metabolism of dietary fat, and as a simple dietary fiber.

  本发明涉及新型 N-酰基和 N-烷基改性季铵盐多糖纤维，或同时涉及 N-酰基和 N-烷基改性季铵盐多糖纤维以及包含改性纤维的药物组合物。此外，本发明还涉及使用此类改性多糖纤维降低胆固醇、降低哺乳动物对作为热量的膳食脂肪的吸收和代谢利用或作为膳食纤维补充剂的工艺。多糖可以用季铵侧链改性，季铵侧链能够封存胆盐，而多糖的其他部分则吸收大量油脂，同时将改性多糖和油脂复合物消散在水性消化液和固体中。N-Acyl 改性多糖中间体还可用于降低胆固醇、减少膳食脂肪的吸收和代谢，并可作为一种简单的膳食纤维。