2-amino-2-methyl-4-[5-(4-benzyloxyphenyl)thiophen-2-yl]butan-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-amino-2-methyl-4-[5-(4-benzyloxyphenyl)thiophen-2-yl]butan-1-ol
• 英文别名: 2-Amino-2-methyl-4-[5-(4-phenylmethoxyphenyl)thiophen-2-yl]butan-1-ol
• 化学式: C₂₂H₂₅NO₂S
• 分子量: 367.512
• InChiKey: KXVWHVSCXAHXAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  83.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Amino alcohol derivatives
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20030236297A1

  公开（公告）日：2003-12-25

  Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: 1 wherein R 1 and R 2 are a hydrogen atom, an amino protecting group; R 3 is a hydrogen atom, a hydroxy protecting group; R 4 is a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C 1 -C 10 alkylene group, a C 1 -C 10 alkylene group substituted with 1 to 3 substituents selected from substituent group a and b; R 5 is an aryl group; R 6 and R 7 are a hydrogen atom, a group selected from substituent group a; with the proviso when R 5 is a hydrogen atom, Y is not a single bond or a straight chain C 1 -C 10 alkylene group.

  式（I）的化合物表现出优异的免疫抑制活性，其药理学上可接受的盐，酯或其他衍生物：其中R1和R2是氢原子，氨基保护基；R3是氢原子，羟基保护基；R4是较低的烷基基团；n是1到6之间的整数；X是乙烯基团；Y是C1-C10烷基基团，带有1到3个从取代基a和b中选择的取代基的C1-C10烷基基团；R5是芳基基团；R6和R7是氢原子，从取代基a中选择的基团；但是当R5是氢原子时，Y不是单键或直链的C1-C10烷基基团。
• AMINO ALCOHOL DERIVATIVES
  申请人：Sankyo Company, Limited

  公开号：EP1300405A1

  公开（公告）日：2003-04-09

  The present invention relates to compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: wherein R1 and R2 are a hydrogen atom, an amino protecting group; R3 is a hydrogen atom, a hydroxy protecting group; R4 is a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C1-C10 alkylene group, a C1-C10 alkylene group substituted with 1 to 3 substituents selected from substituent group a and b; R5 is an aryl group; R6 and R7 are a hydrogen atom, a group selected from substituent group a; with the proviso when R5 is a hydrogen atom, Y is not a single bond or a straight chain C1-C10 alkylene group.

  本发明涉及具有优异免疫抑制活性的式(I)化合物、其药理学上可接受的盐、酯或其它衍生物： 其中，R1 和 R2 是氢原子、氨基保护基；R3 是氢原子、羟基保护基；R4 是低级烷基；n 是 1 至 6 的整数；X 是乙烯基；Y 是 C1-C10 亚烷基、被 1 至 3 个选自取代基 a 和 b 的取代基取代的 C1-C10 亚烷基；R5是芳基；R6和R7是氢原子、选自取代基a的基团；但当R5是氢原子时，Y不是单键或直链C1-C10亚烷基。
• US6723745B2
  申请人：——

  公开号：US6723745B2

  公开（公告）日：2004-04-20
• US6964976B2
  申请人：——

  公开号：US6964976B2

  公开（公告）日：2005-11-15