6,8-Bis[(2-amino-2-oxoethyl)sulfanyl]octanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6,8-Bis[(2-amino-2-oxoethyl)sulfanyl]octanoic acid
• 化学式: C₁₂H₂₂N₂O₄S₂
• 分子量: 322.4
• InChiKey: CKIYZDFXMSBGGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  174
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• LIPOIC ACID DERIVATIVES
  申请人：BINGHAM PAUL

  公开号：US20080262034A1

  公开（公告）日：2008-10-23

  Lipoic acid derivatives and pharmaceutical formulations containing lipoic acid derivatives are useful in the treatment and prevention of disease characterized by disease cells that are sensitive to lipoic acid derivatives.

  硫辛酸衍生物和含有硫辛酸衍生物的药物配方在治疗和预防由对硫辛酸衍生物敏感的疾病细胞所特征的疾病中是有用的。
• Lipoic acid derivatives and their use in treatment of disease
  申请人：The Research Foundation of State University of New York

  公开号：EP1486495A1

  公开（公告）日：2004-12-15

  The invention provides a method of inhibiting proliferation of diseased cells by contacting the diseased cells with an effective amount of a reagent that inhibits PDC specifically in said diseased cells.

  本发明提供了一种抑制病变细胞增殖的方法，方法是将病变细胞与有效量的试剂接触，该试剂可特异性地抑制病变细胞中的 PDC。
• Dibenzyl lipoic acid derivatives and their use in treatment of disease
  申请人：The Research Foundation Of The State University Of New York

  公开号：EP2145883A1

  公开（公告）日：2010-01-20

  The invention provides a method of inhibiting proliferation of diseased cells by contacting the diseased cells with an effective amount of a reagent that inhibits PDC specifically in said diseased cells.

  本发明提供了一种抑制病变细胞增殖的方法，方法是将病变细胞与有效量的试剂接触，该试剂可特异性地抑制病变细胞中的 PDC。
• Methods for treating cancer using 6,8-bis (benzylthio) octanonic acid
  申请人：Rafael Pharmaceuticals, Inc.

  公开号：US10391177B2

  公开（公告）日：2019-08-27

  Pharmaceutical formulations containing lipoic acid derivatives and ion pairs thereof are described. The pharmaceutical formulations are useful in the treatment of medical disorders, such as cancer.

  描述了含有硫辛酸衍生物及其离子对的药物制剂。这些药物制剂可用于治疗癌症等内科疾病。
• Methods of treating leukemia using compositions containing bis(benzylthio)octanoic acid and ion pairs thereof
  申请人：Rafael Pharmaceuticals, Inc.

  公开号：US11065335B2

  公开（公告）日：2021-07-20

  Pharmaceutical formulations containing lipoic acid derivatives and ion pairs thereof are described. The pharmaceutical formulations are useful in the treatment of medical disorders, such as cancer.

  描述了含有硫辛酸衍生物及其离子对的药物制剂。这些药物制剂可用于治疗癌症等内科疾病。