2-[4-[1,2-bis(hydroxymethyl)-6,7-dihydro-5H-pyrrolizin-3-yl]-N-methylanilino]ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-[4-[1,2-bis(hydroxymethyl)-6,7-dihydro-5H-pyrrolizin-3-yl]-N-methylanilino]ethanol
• 化学式: C₁₈H₂₄N₂O₃
• 分子量: 316.4
• InChiKey: YOPSSMCTQMDBPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  68.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] NOVEL OLIGONUCLEOTIDE COMPOUNDS HAVING PYRROLIZINE DERIVATIVES, PROCESSES FRO PREPARING THEM, COMPOSITIONS CONTAINING THEM AND USES THEREOF IN TREATMENT, DIAGNOSIS AND ANALYSIS OF GENE-RELATED DISEASES<br/>[FR] NOUVEAUX COMPOSES D'OLIGONUCLEOTIDES RENFERMANT DES DERIVES DE PYRROLIZINE, METHODES DE PREPARATION CORRESPONDANTES, COMPOSITIONS LES CONTENANT ET UTILISATIONS CORRESPONDANTES DANS LE TRAITEMENT, LE DIAGNOSTIC ET L'ANALYSE DE MALADIES GENETIQUES
  申请人：GENECHEM INC

  公开号：WO2001092285A1

  公开（公告）日：2001-12-06

  Disclosed is a novel compound, represented by formula (1), in which oligonucleotide or analogue thereof that is capable of bonding with genes (DNA or RNA) site-specifically has pyrrolizine derivatives that form covalent bonding with specified base groups of the genes (DNA or RNA) and a process for preparing the same. Also, the present invention relates to a use of the compound in wide range, as site-specifically target substances in fields related of treatment diagnosis and analysis of gene-related diseases. Formula (1) wherein, R1, X, X', Y and n are as defined in the description.