1,1'-(1,3-亚苯基) 2-丙烯酸酯 | 35289-72-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 1,1'-(1,3-亚苯基) 2-丙烯酸酯
• 中文别名: 1,1'-(1,3-亚苯基)2-丙烯酸酯
• 英文名称: 1,3-Bisacryloyloxybenzol
• 英文别名: 1,3-Phenylenediacrylate；(3-prop-2-enoyloxyphenyl) prop-2-enoate
• CAS: 35289-72-6
• 化学式: C₁₂H₁₀O₄
• 分子量: 218.209
• InChiKey: YLCILCNDLBSOIO-UHFFFAOYSA-N

物化性质

• 沸点：
  355.4±12.0 °C(Predicted)
• 密度：
  1.161±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  1,1'-(1,3-亚苯基) 2-丙烯酸酯 、 (S)-methyl 2-(trifluoromethylsulfonamido)-3-(1-(triisopropylsilyl)-1H-indol-3-yl)propanoate 在 silver(I) acetate 、 palladium diacetate 、 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以65%的产率得到
  参考文献：
  名称：

  钯催化色氨酸的位点选择性CH Oleflation后期肽大环化。

  摘要：

  过渡金属催化的CH活化在具有扩大的结构多样性的肽的功能化中显示出潜力。本文报道了通过钯催化的C2和C4位色氨酸残基的位点选择性C（sp 2）-H烯化钯催化后期肽大环化方法的发展。该策略利用肽骨架作为内源性指导基团，并提供具有独特的Trp-烯烃交联键的肽大环化合物。

  DOI：

  10.1002/anie.202007226

文献信息

• Distal <i>meta</i>-C–H functionalization of α-substituted cinnamates
  作者：Manickam Bakthadoss、Tadiparthi Thirupathi Reddy

  DOI：10.1039/d2sc06206b

  日期：——

  Development of a novel strategy for the palladium-catalyzed selective meta-C–H activation of α-substituted cinnamates and their heterocyclic analogues with various alkenes using nitrile as a directing group (DG) has been described. Importantly, we introduced naphthoquinone, benzoquinones, maleimides and sulfolene as coupling partners in the meta-C–H activation reaction for the first time. Notably,

  已经描述了使用腈作为导向基团 (DG) 的钯催化选择性间位-C-H 活化α-取代肉桂酸酯及其与各种烯烃的杂环类似物的新策略。重要的是，我们首次引入萘醌、苯醌、马来酰亚胺和环丁砜作为间位-C-H 活化反应中的偶联伙伴。值得注意的是，烯丙基化、乙酰氧基化和氰化也是通过远端间位-C-H 功能化实现的。这种新颖的协议还包括具有高选择性的各种烯烃系生物活性分子的耦合。
• COMPOUND, POLYMER, ORGANIC MATERIAL, AND OPTICAL DEVICE, OPTICAL COMPONENT, AND IMAGE DISPLAY DEVICE ALL INCLUDING SAID ORGANIC MATERIAL
  申请人：Sony Group Corporation

  公开号：EP3995491A1

  公开（公告）日：2022-05-11

  To provide a compound that is capable of improving the function of an organic material. The present technology provides a compound represented by the following general formula (1). In the general formula (1), X1 represents an oxygen atom, a nitrogen atom, a phosphorus atom, a caron atom, or a silicon atom. Y1 and Y2 each represent a benzene ring or a naphthalene ring, and both Y1 and Y2 do not represent benzene rings. R1 to R3 each represent a hydrogen or a substituent group represented by *-Z1(R4)d (* represents a bonding site). Z1 represents a single bond, a saturated hydrocarbon group having a valence of 2 or higher, or an unsaturated hydrocarbon group having a valence of 2 or higher, the saturated hydrocarbon group or the unsaturated hydrocarbon group optionally having an ether bond and/or a thioether bond. R4 represents a hydrogen or a polymerizable substituent group.

  提供一种能够改善有机材料功能的化合物。 本技术提供了一种由以下通式（1）表示的化合物。 在通式（1）中，X1 代表氧原子、氮原子、磷原子、碳原子或硅原子。 Y1 和 Y2 各自代表苯环或萘环，Y1 和 Y2 都不代表苯环。 R1 至 R3 各自代表氢或由 *-Z1(R4)d（* 代表键合位点）代表的取代基。 Z1 代表单键、化合价为 2 或更高的饱和烃基或化合价为 2 或更高的不饱和烃基，饱和烃基或不饱和烃基可选择具有醚键和/或硫醚键。 R4 代表氢或可聚合取代基。
• CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF
  申请人：Anderson Daniel Griffith

  公开号：US20080145338A1

  公开（公告）日：2008-06-19

  Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
• End-Modified Poly(beta-amino esters) and Uses Thereof
  申请人：Zugates Gregory T.

  公开号：US20080242626A1

  公开（公告）日：2008-10-02

  Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
• METHODS AND COMPOSITIONS FOR IMPROVED THERAPEUTIC EFFECTS WITH siRNA
  申请人：Berry David Arthur

  公开号：US20080311040A1

  公开（公告）日：2008-12-18

  The present invention relates to chemically modified, linked double-stranded (ds)RNA compositions comprising two or more double-stranded (ds) oligoribonucleotides linked by at least one linking moiety and methods of formulating and delivering such compositions to modulate gene expression through target-specific RNA co-interference (RNAco-i). The compositions of the invention may optionally comprise a conjugation or a complex with one or more small molecule drugs, protein therapeutics, or other dsRNA molecules. The present invention is directed at the methods of production for, methods of use of, and therapeutic utilities for RNAi co-interference therapy utilizing the compositions of the invention.