(5S,6E,8Z,10E,12E,14R,15S)-20,20,20-trifluoro-5,14,15-trihydroxy-5-methylicosa-6,8,10,12-tetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5S,6E,8Z,10E,12E,14R,15S)-20,20,20-trifluoro-5,14,15-trihydroxy-5-methylicosa-6,8,10,12-tetraenoic acid
• 化学式: C₂₁H₃₁F₃O₅
• 分子量: 420.5
• InChiKey: RDLVTAMOKVDZDQ-WWHYYZBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  29
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Modulation of Inflammation Related to Columnar Epithelia
  申请人：Madara L. James

  公开号：US20080064660A1

  公开（公告）日：2008-03-13

  This invention provides pharmaceutical compositions containing lipoxin compounds and therapeutic uses for the compounds in treating or preventing a disease or condition associated with columnar epithelial inflammation. The invention also discloses methods for screening for compounds useful in preventing columnar epithelial inflammation.
• METHOD FOR TREATING AIRWAY HYPER-RESPONSIVENESS WITH LIPOXIN ANALOGS
  申请人：Serhan Charles N.

  公开号：US20120149771A1

  公开（公告）日：2012-06-14

  The use of lipoxin analogs for the treatment or prevention of asthma and asthma related diseases is described. In particular, acetylenic lipoxin analogs are effective for the treatment and prevention of eosinophil recruitment involved with the inflammation processes associated with asthma, asthma like conditions, and lung injuries associated from airway inflammation or infection as brought about by leukocyte-mediated injury from within.
• US8440718B2
  申请人：——

  公开号：US8440718B2

  公开（公告）日：2013-05-14