1,1':4',1''-三联苯-4-硫醇 | 90589-98-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,1':4',1''-三联苯-4-硫醇
• 中文别名: 2-咪唑烷酮,1-(3-甲基-1-羰基丁基)-；1,1′,4′,1′′-三联苯-4-硫醇
• 英文名称: 1,1';4',1''-terphenyl-4-thiol
• 英文别名: p-terphenyl-4-thiol；4-Terphenylthiol；4-(4-phenylphenyl)benzenethiol
• CAS: 90589-98-3
• 化学式: C₁₈H₁₄S
• 分子量: 262.375
• InChiKey: KDECGGARTQDFEI-UHFFFAOYSA-N

物化性质

• 熔点：
  246-252°C

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  对三联苯 在 氯磺酸 、 lithium aluminium tetrahydride 、 五氯化磷 作用下， 反应 3.0h， 生成 1,1':4',1''-三联苯-4-硫醇
  参考文献：
  名称：

  Fabrication of a Carboxyl-Terminated Organic Surface with Self-Assembly of Functionalized Terphenylthiols:  The Importance of Hydrogen Bond Formation

  摘要：

  Self-assembled monolayers (SAMs) were prepared from different oligophenylthiol molecules (terphenylthiol, (C6H5C6H4C6H4SH, TPT), terphenylmethanethiol (C6H5C6H4C6H4CH2SH, TPMT), and carboxy terphenylmethanethiol (HOOCC6H4C6H4C6H4CH2SH, CTPMT)) on Au substrates. Compared to the more commonly used alkanethiols this class of organothiols has a much more rigid backbone. It is demonstrated that for organothiols with a strongly interacting function at the omega-position the larger mechanical rigidity significantly affects the molecular structure of the self-assembled films. Whereas the unsubstituted terphenylthiols, TPT and TPMT, form well-ordered monolayers with an average tilt angle of 27 degrees +/- 5 degrees, immersion into ethanolic solutions of the COOH-functionalized terphenylmethanethiol CTPMT yields highly oriented bilayers. The second layer is linked to the first layer by hydrogen bonds. This double-layer formation has not been observed for the corresponding alkanethiols. Single layers of CTPMT on gold could, however, be prepared by adsorption from a mixture with trifluoroacetic acid (TFA) or by immersion of the bilayers into TFA. The immersion of the bilayers into potassium hydroxide solutions leads to the intercalation of potassium ions into the bilayers without removal of the second layer.

  DOI：

  10.1021/ja981872s

文献信息

• DISPERSION
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3305853A1

  公开（公告）日：2018-04-11

  A dispersion which contains a dispersant and particles selected from among metal particles and metal oxide particles, and which is characterized in that: the dispersant has a chemical structure that is able to be bonded or adsorbed to the particles; and the dispersant contains a low-molecular-weight dispersant that has at least one peak within a molecular weight region of 31 or more but less than 1,000 in the molecular weight distribution curve in terms of polyethylene glycol as determined by gel permeation chromatography and a high-molecular-weight dispersant that has at least one peak within a molecular weight region of 1,000 or more but 40,000 or less in the above-described molecular weight distribution curve.

  一种分散剂，它含有一种分散剂和选自金属颗粒和金属氧化物颗粒的颗粒，其特征在于分散剂的化学结构能与颗粒结合或吸附；分散剂含有一种低分子量分散剂，该分散剂在凝胶渗透色谱法测定的聚乙二醇分子量分布曲线中，至少有一个峰值在 31 或以上但小于 1,000 的分子量区域内；还含有一种高分子量分散剂，该分散剂在上述分子量分布曲线中，至少有一个峰值在 1,000 或以上但小于 40,000 的分子量区域内。
• Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles
  申请人：Medcom Advance, S.A

  公开号：US10150160B2

  公开（公告）日：2018-12-11

  The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.

  SERS 编码纳米粒子的通用单锅可放大合成方法依赖于纳米粒子金属表面对巯基十一酸（MUA）和拉曼代码的可控共吸收。与大多数通常涉及复杂步骤的报告程序相比，本方法已证明是一种简单、快速的一锅式 SERS 编码纳米粒子生产方法。这种多用途的策略可以将每一种对金属表面具有亲和力的分子进行 SERS 编码，而不管其化学性质如何，在这里使用相同的标准程序制备出 31 种不同的编码颗粒就是一个例子。我们的 SERS 编码颗粒不仅制备简单、可扩展到升浓度、在水溶液（包括 PBS）中稳定，而且化学性质多样，与使用 PEG 或 PVP 聚合物制备的颗粒相比，我们的 SERS 编码颗粒显示出更高的光学效率。
• Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
  申请人：Microbion Corporation

  公开号：US10835510B2

  公开（公告）日：2020-11-17

  Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and/or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.

  本文描述了用于治疗急性伤口、慢性伤口和/或含有细菌生物膜的伤口或上皮组织表面的组合物和方法，包括新型均匀微粒悬浮液，包括铋硫醇（BT）化合物与某些抗生素之间意想不到的协同作用，以提供局部制剂，包括防腐制剂，用于管理和促进伤口愈合，特别是感染伤口。此外，还描述了已公开的 BT 化合物和 BT 化合物加抗生素组合物以前未曾预料到的抗菌特性和抗生物膜特性，包括某些此类组合物治疗革兰氏阳性细菌感染的优先功效，以及某些此类组合物治疗革兰氏阴性细菌感染的独特优先功效。
• Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
  申请人：Microbion Corporation

  公开号：US10960012B2

  公开（公告）日：2021-03-30

  Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.

  介绍了用于处理含有细菌生物膜的天然表面的组合物和方法，包括新型均质微粒悬浮剂，包括铋硫醇（BT）化合物和某些抗生素之间意想不到的协同作用或增强效果，以提供包括防腐制剂在内的配方。此外，还描述了所公开的 BT 化合物和 BT 化合物加抗生素组合物以前未曾预料到的抗菌特性和抗生物膜特性，包括某些此类组合物治疗某些革兰氏阳性细菌感染的优先功效，以及某些此类组合物治疗某些革兰氏阴性细菌感染的独特优先功效。
• Covalent treatment with thiols of keratin-containing materials
  申请人：Living Proof, Inc.

  公开号：US10993903B2

  公开（公告）日：2021-05-04

  Disclosed are methods of preparing thiol keratin-containing materials, comprising applying a mixture comprising one or more thiol compounds and a catalyst. Methods of preparing cross-linked keratin-containing materials by applying a mixture comprising one or more thiol compounds and an oxidizing agent are also disclosed. Methods of grafting monomeric and polymeric materials on keratin-containing materials to provide a covalent coating on keratin-containing materials are disclosed. A mixture comprising one or more thiol compounds is applied to the keratin-containing material sample. The keratin-containing material sample then comprises a plurality of free thiol groups. A monomer is optionally applied to the keratin-containing material sample to form a plurality of covalent bonds between the free thiol groups and the monomers. The disclosed grafting methods can be carried out with or without catalyst.

  本发明公开了制备含硫醇角蛋白材料的方法，包括使用由一种或多种硫醇化合物和催化剂组成的混合物。还公开了通过使用由一种或多种硫醇化合物和氧化剂组成的混合物制备交联含角蛋白材料的方法。公开了在含角蛋白材料上接枝单体和聚合物材料以在含角蛋白材料上提供共价涂层的方法。将包含一种或多种硫醇化合物的混合物涂抹在含角蛋白材料样品上。这样，含角蛋白材料样品就含有多个游离硫醇基团。可选择将单体应用于含角蛋白材料样品，以在游离硫醇基团和单体之间形成多个共价键。所公开的接枝方法可在使用或不使用催化剂的情况下进行。