4-(2-Chloro-phenyl)-1-(3,4-dimethoxy-benzyl)-6-methyl-1,4-dihydro-pyridine-2,3,5-tricarboxylic acid 5-isopropyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-(2-Chloro-phenyl)-1-(3,4-dimethoxy-benzyl)-6-methyl-1,4-dihydro-pyridine-2,3,5-tricarboxylic acid 5-isopropyl ester
• 英文别名: 4-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-6-methyl-5-propan-2-yloxycarbonyl-4H-pyridine-2,3-dicarboxylic acid
• 化学式: C₂₇H₂₈ClNO₈
• 分子量: 529.974
• InChiKey: VQAWZPKKNZUGCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基苄胺 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 生成 4-(2-Chloro-phenyl)-1-(3,4-dimethoxy-benzyl)-6-methyl-1,4-dihydro-pyridine-2,3,5-tricarboxylic acid 5-isopropyl ester
  参考文献：
  名称：

  Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors

  摘要：

  The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented. SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00798-4

文献信息

• Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors
  作者：Anthony K. Ogawa、Chris A. Willoughby、Raynald Bergeron、Kenneth P. Ellsworth、Wayne M. Geissler、Robert W. Myers、Jun Yao、Georgianna Harris、Kevin T. Chapman

  DOI：10.1016/s0960-894x(03)00798-4

  日期：2003.10

  The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented. SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model. (C) 2003 Elsevier Ltd. All rights reserved.