(2S)-3-[4-[4-[(1H-benzimidazol-2-ylamino)methyl]piperidin-1-yl]-5-methyl-2-oxopyrimidin-1-yl]-2-(dimethylsulfamoylamino)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-3-[4-[4-[(1H-benzimidazol-2-ylamino)methyl]piperidin-1-yl]-5-methyl-2-oxopyrimidin-1-yl]-2-(dimethylsulfamoylamino)propanoic acid
• 化学式: C₂₃H₃₂N₈O₅S
• 分子量: 532.6
• InChiKey: HOAYDYVTWLEYOW-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  172
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Pyrimidinonesulfamoylureas`
  申请人：——

  公开号：US20030171368A1

  公开（公告）日：2003-09-11

  The disclosure is directed to compounds of the formula (I) 1 wherein the radicals have the meanings described in the disclosure, to the preparation of the compounds and to the use of the compounds to find the integrin receptors.

  本公开涉及式(I)1的化合物，其中基团具有公开说明中所描述的含义，以及制备该化合物和使用该化合物寻找整合素受体的方法。
• [EN] PYRIMIDINONESULFAMOYLUREAS AS INTEGRIN LIGANDS<br/>[FR] PYRIMIDINONESULFAMOYLUREES EN TANT QUE LIGANSDS DE L'INTEGRINE
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2003066624A1

  公开（公告）日：2003-08-14

  The invention relates to novel compounds which bind to integrin receptors, and to their preparation and use. Said compounds have the general formula (I): (Formula I); wherein A, E, R1, R2, T and X are as defined in claim 1.