Dosper

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Dosper
• 英文别名: [2-[2,5-bis(3-aminopropylamino)pentanoylamino]-3-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
• 化学式: C₅₀H₉₇N₅O₅
• 分子量: 848.3
• InChiKey: ZBZZCPZWMAUTSW-CLFAGFIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.1
• 重原子数：
  60
• 可旋转键数：
  49
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  158
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• BRANCHED CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM
  申请人：Zhao Hong

  公开号：US20110305769A1

  公开（公告）日：2011-12-15

  The present invention is directed to cationic lipid for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to cholesterol and its derivatives having multiple positively charged moieties via branching spacers, and nanoparticle compositions of oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.

  本发明涉及用于递送寡核苷酸的阳离子脂质以及利用纳米粒子组合物调节靶向基因表达的方法。具体而言，本发明涉及通过分支间隔物具有多个带正电性的衍生物的胆固醇及其衍生物，以及封装在阳离子脂质、融合脂质和PEG脂质混合物中的寡核苷酸纳米粒子组合物。
• AMINO ACID LIPIDS AND USES THEREOF
  申请人：Quay Steven C.

  公开号：US20080317839A1

  公开（公告）日：2008-12-25

  This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  这份披露提供了一系列氨基酸脂类化合物和组合物，可用于药物传递、治疗、诊断和治疗疾病和病况。这些氨基酸脂类化合物和组合物可用于将各种药剂如核酸治疗剂传递到细胞、组织、器官和受试者中。
• Amino acid lipids and uses thereof
  申请人：Quay Steven C.

  公开号：US20110177160A1

  公开（公告）日：2011-07-21

  This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  本文披露了一系列氨基酸脂类化合物和组合物，可用于药物传递、治疗、疾病和病况的诊断和治疗。氨基酸脂类化合物和组合物可用于将各种药剂如核酸治疗剂传递至细胞、组织、器官和受试者。
• NANOPARTICLE COMPOSITIONS FOR NUCLEIC ACIDS DELIVERY SYSTEM
  申请人：Zhao Hong

  公开号：US20110111044A1

  公开（公告）日：2011-05-12

  The present invention is directed to nanoparticle compositions for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.

  本发明涉及纳米颗粒组合物，用于输送寡核苷酸并使用该纳米颗粒组合物调节靶向基因的表达的方法。特别地，该发明涉及封装在阳离子脂质、融合脂质和PEG脂质混合物中的寡核苷酸。
• TYROSINE-BASED LIPIDS FOR DELIVERY OF THERAPEUTICS
  申请人：Marina Biotech, Inc.

  公开号：US20160206739A1

  公开（公告）日：2016-07-21

  This disclosure provides a range of tyrosine amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  本披露提供了一系列酪氨酸氨基酸脂类化合物和组合物，可用于药物输送、治疗以及疾病和病症的诊断和治疗。这些氨基酸脂类化合物和组合物可用于将各种药剂如核酸治疗剂输送至细胞、组织、器官和受试者。