3-[2,5-Bis(3-aminopropylamino)pentanoylamino]-4-(dioctadecylamino)-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[2,5-Bis(3-aminopropylamino)pentanoylamino]-4-(dioctadecylamino)-4-oxobutanoic acid
• 化学式: C₅₁H₁₀₄N₆O₄
• 分子量: 865.4
• InChiKey: MRBOBAGWABGBNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.7
• 重原子数：
  61
• 可旋转键数：
  50
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  163
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• LIPID DELIVERY FORMULATIONS
  申请人：Brown Bob D.

  公开号：US20130225663A1

  公开（公告）日：2013-08-29

  The invention provides formulations that contain an immunogenic or immunostimulatory cargo, delivery moiety and/or lipid, and a lipid that functions to reduce or prevent induction in a subject of an immune response which would otherwise occur when the immunogenic or immunostimulatory cargo, delivery moiety and/or lipid is administered to a subject as a component of an appropriate control formulation lacking the immune response reducing lipid. Specific immune response reducing lipids and uses thereof are further provided.
• US9320798B2
  申请人：——

  公开号：US9320798B2

  公开（公告）日：2016-04-26
• [EN] LIPID DELIVERY FORMULATIONS<br/>[FR] FORMULATIONS D'ADMINISTRATION DE LIPIDE
  申请人：DICERNA PHARMACEUTICALS INC

  公开号：WO2011109294A1

  公开（公告）日：2011-09-09

  The invention provides formulations that contain an immunogenic or immunostimulatory cargo, delivery moiety and/or lipid, and a lipid that functions to reduce or prevent induction in a subject of an immune response which would otherwise occur when the immunogenic or immunostimulatory cargo, delivery moiety and/or lipid is administered to a subject as a component of an appropriate control formulation lacking the immune response reducing lipid. Specific immune response reducing lipids and uses thereof are further provided.